Evidence map›Paper›PMID 37989586›Full record

Trial reportTobacco control2025

Effect of nicotine corrective messaging on nicotine-related beliefs in US adults: a randomised controlled trial.

Andrea C Villanti, Catherine Peasley-Miklus, Melissa Mercincavage, Darren Mays, Eric C Donny, Joseph N Cappella, Andrew A Strasser

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Tobacco control, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04805515 (Impact of Nicotine Messaging on Nicotine Beliefs and Tobacco Use Behavior), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04805515 nacompletednot on this map

Impact of Nicotine Messaging on Nicotine Beliefs and Tobacco Use Behavior

TypeinterventionalSponsorUniversity of VermontRan2021 to 2021Enrolled794ConditionsNicotine Dependence, CigarettesArmsNicotine Corrective Messages
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Impact of Survey Item Wording and Response Options on Prevalence of Beliefs About Nicotine Causing Cancer: A Randomized Survey Experiment.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
    Trial
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Andrea C VillantiRutgers Institute for Nicotine and Tobacco Studies, Rutgers University, New Brunswick, New Jersey, USA andrea.villanti@rutgers.edu.ORCID 0000-0003-3104-966X
Catherine Peasley-MiklusVermont Center on Behavior and Health, University of Vermont Larner College of Medicine, Burlington, Vermont, USA.
Melissa MercincavageDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Darren MaysDepartment of Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio, USA.ORCID 0000-0002-6605-0743
Eric C DonnyBaptist Comprehensive Cancer Center and Department of Physiology and Pharmacology, Wake Forest University, Winston-Salem, North Carolina, USA.
Joseph N CappellaAnnenberg School for Communication, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Andrew A StrasserDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
University of Pennsylvania · USAtrium Health Wake Forest Baptist · USRutgers, The State University of New Jersey · USThe Ohio State University · USUniversity of Vermont · US

Funding

Tobacco Industry Marketing CoreU54CA229973 · NCI · UNIVERSITY OF PENNSYLVANIA · PI AUDRAIN-MCGOVERN, JANET E · 2018 to 2022
$18.8M
Impact of Nicotine Messaging on Nicotine Beliefs and Tobacco Use BehaviorR01DA051001 · NIDA · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI STRASSER, ANDREW A, VILLANTI, ANDREA · 2020 to 2022
$1.4M
NCI NIH HHS U54 CA229973NIDA NIH HHS R01 DA051001
6 · The paper itself

Abstract

introductionWidespread misperceptions of the health risks of nicotine could undermine the public health benefits of the Food and Drug Administration's actions, including modified risk tobacco product authorisations and a reduced nicotine product standard for cigarettes.

methods794 US adults (aged 18+) in NORC's AmeriSpeak panel participated in a randomised controlled trial in Spring 2021 to test the effect of three exposures to eight nicotine corrective messages (NCM) on beliefs about nicotine, nicotine replacement therapy (NRT), e-cigarettes and reduced nicotine content (RNC) cigarettes at 3-month follow-up. Analyses conducted in 2022 examined the effect of study condition (NCM (n=393) vs no message control (n=401)) on nicotine beliefs, use intentions and use of nicotine and tobacco products.

resultsExposure to three NCM doses reduced nicotine (b=-0.33; 95% CI -0.60, -0.07), NRT (b=-0.49; 95% CI -0.85, -0.14), e-cigarette (b=-0.32; 95% CI -0.59, -0.05) and RNC cigarette false beliefs (b=-0.64; 95% CI -1.26, -0.02) compared with the control, controlling for baseline beliefs. Baseline tobacco use and concern about nicotine addiction attenuated intervention effects on false beliefs about RNC cigarettes. There were few intervention effects on intention or use of nicotine and tobacco products.

conclusionsRepeated exposure to NCM was necessary to reduce false beliefs about nicotine and tobacco products. Future studies will improve understanding of the dose and duration of nicotine education needed to shift intentions and behaviour, as well as tailored content for tobacco product users to achieve similar reductions in false beliefs as non-users. TRIAL REGISTRATION NUMBER: NCT04805515.

Indexed as

Health Knowledge, Attitudes, PracticeNicotineSmoking CessationAdolescentAdultElectronic Nicotine Delivery SystemsFemaleHumansIntentionMaleMiddle AgedTobacco ProductsTobacco Use Cessation DevicesUnited StatesYoung AdultNicotineNicotinePublic opinionPublic policy

Identifiers

PMID37989586
PMCPMC12015006
OpenAlexW4388857812

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.