Evidence map›Paper›PMID 37988935›Full record

ReviewCancer treatment and research communications2023

Molecular characterization of plasmacytoid urothelial carcinoma and the impact on treatment implications.

Kristin Weiss, Kathryn H Gessner, Alysen Demzik, Elizabeth Moreton, William Y Kim, Sara E Wobker, Tracy L Rose, Matthew I Milowsky, Marc A Bjurlin

Open access · goldAbstract readReview
In one paragraph

Review in Cancer treatment and research communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kristin WeissUniversity of North Carolina School of Medicine, Chapel Hill, NC, USA.
Kathryn H GessnerUniversity of North Carolina Department of Urology, Chapel Hill, NC, USA.
Alysen DemzikUniversity of North Carolina Department of Urology, Chapel Hill, NC, USA.
Elizabeth MoretonUniversity of North Carolina Libraries System, Chapel Hill, NC, USA.
William Y KimLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, NC, USA; Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, NC, USA; Department of Genetics, University of North Carolina at Chapel Hill, NC, USA.
Sara E WobkerUniversity of North Carolina Department of Urology, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC, USA; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, NC, USA.
Tracy L RoseLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC, USA; Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, NC, USA.
Matthew I MilowskyLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC, USA; Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, NC, USA.
Marc A BjurlinUniversity of North Carolina Department of Urology, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC, USA. Electronic address: marc_bjurlin@med.unc.edu.
University of North Carolina at Chapel Hill · USUniversity of North Carolina System · US

Funding

UNC Integrated Translational Oncology Program (UNC-iTOP)T32CA244125 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WILLIAM Y. KIM, Jen Jen Yeh · 2019 to 2026
$3.9M
Selective histone deacetylase inhibition with entinostat to enhance the anti-tumor immune response to immune checkpoint inhibition in urothelial cancerK08CA248967 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROSE, TRACY L · 2020 to 2022
$787k
NCI NIH HHS K08 CA248967NCI NIH HHS T32 CA244125
6 · The paper itself

Abstract

Bladder cancer researchers and clinicians have increasingly viewed tumor biology through the lens of genomic and molecular alterations, drastically improving our knowledge of the underlying disease biology. This understanding has led to significant advances in treatment options that allow implementation of a personalized approach to cancer treatment. Large-scale genomic studies initially focused on the most common forms of bladder cancer. However, as genomic and molecular technologies become more widespread and are applied to less common variant histologies, we are gaining additional insight into the unique molecular and genomic characteristics driving the biology of variant histologies of bladder cancer. In this review, we summarize the current state of knowledge of molecular alterations underlying the distinct tumor biology of plasmacytoid urothelial carcinoma and how these alterations may impact treatment options.

Indexed as

Carcinoma, Transitional CellUrinary Bladder NeoplasmsGenomicsHumansBladder cancerMolecular characterizationPlasmacytoidUrothelial carcinoma

Identifiers

PMID37988935
PMCPMC11315140
OpenAlexW4388776312

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.