ArticleProceedings of the National Academy of Sciences of the United States of America2023
Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 11 citations in OpenAlex.
- MALT1 alternative splicing-A molecular rheostat for balancing immune activation and homeostasis.Science advances · 2026Article
- Preventing MALT1-mediated CYLD cleavage induces intestinal dysbiosis and reduces EAE severity.EMBO reports · 2026Article
- RNA-binding proteins and ribonucleoproteins as determinants of immunity.Nature reviews. Immunology · 2026Review
- Article
- Loss of MALT1 Function in a Patient With Combined Immunodeficiency: a Novel Pathogenic Variant and Immunological Insights.Journal of clinical immunology · 2025Article
- Regulation and Function of the Atypical IκBs-Bcl-3, IκBEuropean journal of immunology · 2025Review
- The NF-κB signaling network in the life of T cells.Frontiers in immunology · 2025Review
- Arid5a uses disordered extensions of its core ARID domain for distinct DNA- and RNA-recognition and gene regulation.The Journal of biological chemistry · 2024Article
- Bioinformatic Analysis of Roquin Family Reveals Their Potential Role in Immune System.International journal of molecular sciences · 2024Article
- Regulation of inflammatory diseases via the control of mRNA decay.Inflammation and regeneration · 2024Review
- MALT1 substrate cleavage: what is it good for?Frontiers in immunology · 2024Review
Corrections and comments
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Authors and funding
21 authors at 5 institutions in 1 country.
Henrik Schmidt *Institute for Immunology, Medical Faculty, Biomedical Center, Ludwig-Maximilians-Universität München, Planegg-Martinsried 82152, Germany.
Timsse Raj *Institute for Immunology, Medical Faculty, Biomedical Center, Ludwig-Maximilians-Universität München, Planegg-Martinsried 82152, Germany.ORCID 0000-0002-5065-8092
Thomas J O'NeillResearch Unit Signaling and Translation, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.
Andreas MuschaweckhInstitute for Experimental Neuroimmunology, Technical University of Munich, School of Medicine, Munich 81675, Germany.
Florian GiesertInstitute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.ORCID 0000-0001-6825-8858
Arlinda NegraschusInstitute for Immunology, Medical Faculty, Biomedical Center, Ludwig-Maximilians-Universität München, Planegg-Martinsried 82152, Germany.ORCID 0009-0001-5137-5297
Kai P HoefigResearch Unit Molecular Immune Regulation, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich 81337, Germany.
Gesine BehrensInstitute for Immunology, Medical Faculty, Biomedical Center, Ludwig-Maximilians-Universität München, Planegg-Martinsried 82152, Germany.
Lena EsserInstitute for Immunology, Medical Faculty, Biomedical Center, Ludwig-Maximilians-Universität München, Planegg-Martinsried 82152, Germany.
Christina BaumannResearch Unit Molecular Immune Regulation, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich 81337, Germany.
Regina FeederleMonoclonal Antibody Core Facility, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.ORCID 0000-0002-3981-367X
Carlos Plaza-SirventDepartment of Molecular Immunology, ZKF2, Ruhr-University Bochum, Bochum 44801, Germany.
Arie GeerlofInstitute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.ORCID 0000-0001-7295-9948
Andreas GewiesResearch Unit Signaling and Translation, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.
Sophie E IsayTranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich 81675, Germany.ORCID 0000-0002-0495-2944
Jürgen RulandTranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich 81675, Germany.
Ingo SchmitzDepartment of Molecular Immunology, ZKF2, Ruhr-University Bochum, Bochum 44801, Germany.ORCID 0000-0002-5360-0419
Wolfgang WurstInstitute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.
Thomas KornInstitute for Experimental Neuroimmunology, Technical University of Munich, School of Medicine, Munich 81675, Germany.ORCID 0000-0002-3633-0955
Daniel KrappmannResearch Unit Signaling and Translation, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.ORCID 0000-0001-7640-3234
Vigo HeissmeyerInstitute for Immunology, Medical Faculty, Biomedical Center, Ludwig-Maximilians-Universität München, Planegg-Martinsried 82152, Germany.
Helmholtz Zentrum München · DELudwig-Maximilians-Universität München · DETechnical University of Munich · DERuhr University Bochum · DEMunich Cluster for Systems Neurology · DE
Funding
Deutsche Forschungsgemeinschaft (DFG) SFB-1054 projects B06 #210592381 TRR355 B07 #490846870 #390857198 EXC 2145 (SyNergy)Deutsche Forschungsgemeinschaft (DFG) SPP-1935 #313381103 SFB-1054 projects A03 #210592381 TRR338 #452881907 TRR355 A06 #490846870 HE3359Deutsche Forschungsgemeinschaft (DFG) TRR338 TRR338 C01 #452881907
Abstract
Constitutive activation of the MALT1 paracaspase in conventional T cells of
Indexed as
AutoimmunityEncephalomyelitis, Autoimmune, ExperimentalAnimalsCell DifferentiationInflammationMiceMucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 ProteinReceptors, Antigen, T-CellUbiquitin-Protein LigasesMucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 ProteinRc3h1 protein, mouseReceptors, Antigen, T-CellUbiquitin-Protein Ligasesantigen receptor signalingautoimmunityparacaspaseRNA-binding proteinT cell differentiation
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What OpenQuestion holds
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.