Evidence map›Paper›PMID 37988198›Full record

ArticleAging2023

Investigating EGF and PAG1 as necroptosis-related biomarkers for diabetic nephropathy: an

Yuejun Wang, Linlin Zhang, Zhiping Peng

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 76% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 0 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Yuejun WangDepartment of Geriatrics, Zhejiang Aged Care Hospital, Hangzhou Normal University, Hangzhou 310000, Zhejiang, China.
Linlin ZhangZhejiang Institute for Food and Drug Control, Hangzhou 310012, Zhejiang, China.
Zhiping PengDepartment of Gerontology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310007, Zhejiang, China.
Affiliated Hospital of Hangzhou Normal University · CNZhejiang Chinese Medical University · CNZheJiang Institute For Food and Drug Control · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The current study aims to understand the mechanisms behind regulated cell death (RCD) in diabetic nephropathy and identify related biomarkers through bioinformatics and experimental validation. Datasets of bulk and single-cell RNA sequencing were obtained from public databases and analyzed using gene set variation analysis (GSVA) with gene sets related to RCD, including autophagy, necroptosis, pyroptosis, apoptosis, and ferroptosis. RCD-related gene biomarkers were identified using weighted gene correlation network analysis (WGCNA). The results were verified through experiments with an independent cohort and

Indexed as

Diabetes MellitusDiabetic NephropathiesRegulated Cell DeathAdaptor Proteins, Signal TransducingBiomarkersEpidermal Growth FactorHumansMembrane ProteinsNecroptosisAdaptor Proteins, Signal TransducingBiomarkersEpidermal Growth FactorMembrane ProteinsPAG1 protein, humanbiomarkersdiabetic nephropathyregulated cell death

Identifiers

PMID37988198
PMCPMC10713428
OpenAlexW4388821656

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.