Evidence map›Paper›PMID 37987804›Full record

ArticlePflugers Archiv : European journal of physiology2023

Enzymatic vitamin A

Johanna Gerhards, Leo I Volkov, Joseph C Corbo, Daniela Malan, Philipp Sasse

Open access · hybridAbstract read
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Optogenetics meets physiology.Pflugers Archiv : European journal of physiology · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Johanna GerhardsInstitute of Physiology I, Medical Faculty, University of Bonn, 53125, Bonn, Germany.
Leo I VolkovDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Joseph C CorboDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Daniela MalanInstitute of Physiology I, Medical Faculty, University of Bonn, 53125, Bonn, Germany. daniela.malan@uni-bonn.de.ORCID 0000-0001-9034-6555
Philipp SasseInstitute of Physiology I, Medical Faculty, University of Bonn, 53125, Bonn, Germany. philipp.sasse@uni-bonn.de.ORCID 0000-0002-8502-9472
University of Bonn · DEWashington University in St. Louis · US

Funding

High-throughput identification of causal variants underlying cardiac arrhythmia-related GWAS hitsR01HL149961 · NHLBI · WASHINGTON UNIVERSITY · PI CORBO, JOSEPH · 2020 to 2023
$2.9M
Elucidating the cis-regulatory grammar of human photoreceptorsR01EY030075 · NEI · WASHINGTON UNIVERSITY · PI CORBO, JOSEPH · 2020 to 2023
$2.2M
NEI NIH HHS R01 EY030075NHLBI NIH HHS R01 HL149961
6 · The paper itself

Abstract

Optogenetics is a technology using light-sensitive proteins to control signaling pathways and physiological processes in cells and organs and has been applied in neuroscience, cardiovascular sciences, and many other research fields. Most commonly used optogenetic actuators are sensitive to blue and green light, but red-light activation would allow better tissue penetration and less phototoxicity. Cyp27c1 is a recently deorphanized cytochrome P450 enzyme that converts vitamin A

Indexed as

OptogeneticsVitamin AChannelrhodopsinsHeartHEK293 CellsHumansChannelrhodopsinsVitamin Avitamin A2ChR2Cyp27c1OptogeneticsReaChRVitamin A2

Identifiers

PMID37987804
PMCPMC10730639
OpenAlexW4388845140

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.