ArticleEuropean journal of physical and rehabilitation medicine2024
Neurophysiological underpinnings of an intensive protocol for upper limb motor recovery in subacute and chronic stroke patients.
Article in European journal of physical and rehabilitation medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- On the correlation between training modalities and recovery stages in poststroke robotic rehabilitation of the upper limb: a systematic review.Journal of neuroengineering and rehabilitation · 2026Pooled it
- Robot-Assisted Upper-Limb Rehabilitation After Stroke: A Systematic Review and Meta-Analysis of Cortical Reorganization and Neuroplasticity Biomarkers.Neural plasticity · 2026Pooled it
- Enhancing upper limb motor recovery prediction after acute stroke using EEG and subacute data.APL bioengineering · 2026Article
- A multimodal machine learning approach to forecast upper limb motor recovery after stroke using kinematic and electromyographic data - A pilot-study.Journal of neuroengineering and rehabilitation · 2026Article
- Article
- Post-stroke spontaneous motor recovery in mice can be predicted from acute-phase local field potential using machine learning.APL bioengineering · 2025Article
- A Game-Based Mechatronic Device for Digital Rehabilitation of Hand Function After a Stroke: Design, Prototyping, and Feasibility Study.JMIR neurotechnology · 2025Article
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9 authors.
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Abstract
backgroundUpper limb (UL) motor impairment following stroke is a leading cause of functional limitations in activities of daily living. Robot-assisted therapy supports rehabilitation, but how its efficacy and the underlying neural mechanisms depend on the time after stroke is yet to be assessed.
aimWe investigated the response to an intensive protocol of robot-assisted rehabilitation in sub-acute and chronic stroke patients, by analyzing the underlying changes in clinical scores, electroencephalography (EEG) and end-effector kinematics. We aimed at identifying neural correlates of the participants' upper limb motor function recovery, following an intensive 2-week rehabilitation protocol.
designProspective cohort study.
settingInpatients and outpatients from the Neurorehabilitation Unit of Pisa University Hospital, Italy. POPULATION: Sub-acute and chronic stroke survivors.
methodsThirty-one stroke survivors (14 sub-acute, 17 chronic) with mild-to-moderate UL paresis were enrolled. All participants underwent ten rehabilitative sessions of task-oriented exercises with a planar end-effector robotic device. All patients were evaluated with the Fugl-Meyer Assessment Scale and the Wolf Motor Function Test, at recruitment (T0), end-of-treatment (T1), and one-month follow-up (T2). Along with clinical scales, kinematic parameters and quantitative EEG were collected for each patient. Kinematics metrics were related to velocity, acceleration and smoothness of the movement. Relative power in four frequency bands was extracted from the EEG signals. The evolution over time of kinematic and EEG features was analyzed, in correlation with motor recovery.
resultsBoth groups displayed significant gains in motility after treatment. Sub-acute patients displayed more pronounced clinical improvements, significant changes in kinematic parameters, and a larger increase in Beta-band in the motor area of the affected hemisphere. In both groups these improvements were associated to a decrease in the Delta-band of both hemispheres. Improvements were retained at T2.
conclusionsThe intensive two-week rehabilitation protocol was effective in both chronic and sub-acute patients, and improvements in the two groups shared similar dynamics. However, stronger cortical and behavioral changes were observed in sub-acute patients suggesting different reorganizational patterns. CLINICAL REHABILITATION IMPACT: This study paves the way to personalized approaches to UL motor rehabilitation after stroke, as highlighted by different neurophysiological modifications following recovery in subacute and chronic stroke patients.
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