ArticleClocks & sleep2023
Effects of Vortioxetine on Sleep Architecture of Adolescents with Major Depressive Disorder.
Article in Clocks & sleep, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed.
- Rapid Eye Movement Sleep Suppressing Antidepressant Prescription is Associated with Improved Survival in Amyotrophic Lateral Sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- A pharmacovigilance study of vortioxetine based on data from the FDA adverse event reporting system.Scientific reports · 2025Article
- The Pathogenesis and Treatment of Insomnia Combined with Depression.International journal of general medicine · 2025Review
- A non-neurodegenerative REM parasomnia with immersive dreaming and dream-reality confusion: a case report.Frontiers in sleep · 2025Article
- The role of sleep disturbances in the onset and maintenance of psychiatric disorders in childhood and adolescence: A review of subjective and polysomnographic findings.Current sleep medicine reports · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The relationship between depression and insomnia is bidirectional and both conditions need to be treated adequately, especially in a vulnerable neurodevelopmental stage of adolescence. This study aimed to evaluate the effects of antidepressant treatment using vortioxetine (VOR) on the sleep architecture of depressed adolescents by using video-polysomnography (v-PSG), which has not been researched before. The v-PSG was performed on 30 adolescent in-patients (mean age of 15.0 years ± 1.5 SD, 21 girls) treated with VOR (dosage of 10/15/20 mg/day) administered orally once a day, before and after VOR treatment. The evaluated parameters were conventional sleep parameters, sleep fragmentation parameters, and selected spectral power indices. Symptoms of depression and insomnia before and after the treatment period were evaluated using valid and reliable questionnaires (the Children´s Depression Inventory and the Athens Insomnia Scale). Depressed adolescents showed higher REM latency and decreased REM sleep percentage after treatment than before the treatment period (
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