Evidence map›Paper›PMID 37987301›Full record

ArticleAdvances in respiratory medicine2023

Investigating Forkhead Box O Transcription Factor 1 Gene's Relation to Immunoglobulin E in House Dust Mite-Allergic Asthma Patients.

Rania A Mohamed, Ahmed ElSadek Fakhr, Shereen A Baioumy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in respiratory medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Rania A MohamedDepartment of Biology, Deanship of Educational Services, Qassim University, P.O. Box 5888, Unaizah 56219, Qassim, Saudi Arabia.ORCID 0000-0001-9540-6297
Ahmed ElSadek FakhrMedical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, P.O. Box 44516, Zagazig 44519, Egypt.ORCID 0000-0002-0497-4908
Shereen A BaioumyMedical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, P.O. Box 44516, Zagazig 44519, Egypt.ORCID 0000-0002-2188-6790
Zagazig University · EGQassim University · SA

Funding

Qassim University, represented by the Deanship of Scientific Research 10236-des-2020-1-3-I
6 · The paper itself

Abstract

House dust mite (HDM)-allergic asthma is an abnormal immune response to extrinsic aeroallergens found in human vicinities. Studying the role of the associated immunity biomarkers and their interplay helps in discovering novel therapeutic strategies that can be used in adjunct with effective long-term immunotherapy. This study investigates the total serum IgE, FoxO1, and Sirtuin 1 (SIRT1) gene expressions in HDM-allergic asthma patients. We enrolled 40 patients for each of the following three groups: an HV group of healthy volunteers and HDM/AA and HDM/SCIT groups of HDM-allergic asthma patients who did not and who did receive immunotherapy before recruitment in this study, respectively. The results elucidated that total IgE was strikingly elevated in the HDM/AA group and showed little decline in the HDM/SCIT group. Both FoxO1 and SIRT1 gene expressions showed the highest levels in the HDM/SCIT group. There was a negative correlation between total IgE and both FoxO1 and SIRT1 in the HDM/AA group while there was a positive correlation with SIRT1 in the HDM/SCIT group. In conclusion, the interplay of the three immunity biomarkers related to HDM-allergic asthma after the course of immunotherapy treatment suggests further, broader studies on the feasibility of their role as immunity biomarkers in the control and remission of HDM-allergic asthma.

Indexed as

AsthmaImmunoglobulin EAnimalsBiomarkersDermatophagoides pteronyssinusDesensitization, ImmunologicForkhead Transcription FactorsHumansPyroglyphidaeSirtuin 1BiomarkersForkhead Transcription FactorsImmunoglobulin ESirtuin 1allergic asthmaFoxO1gene expressionHDMSIRT1total IgE

Identifiers

PMID37987301
PMCPMC10660720
OpenAlexW4388722357

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.