In one paragraphArticle in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
20 authors at 10 institutions in 4 countries.
Lesley WuDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.ORCID 0000-0001-5464-5603 Raquel RealDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.ORCID 0000-0001-8117-742X Alejandro MartinezDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.ORCID 0000-0001-6191-1703 Ruth ChiaNeuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.ORCID 0000-0002-4709-7423 Michael A LawtonPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2PS, UK.ORCID 0000-0002-3419-0354 Maryam ShoaiAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.ORCID 0000-0003-2499-8533 Catherine BresnerInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff CF24 4HQ, UK.ORCID 0000-0003-2673-9762 Leon HubbardInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff CF24 4HQ, UK.ORCID 0000-0002-0064-6755 Cornelis BlauwendraatIntegrative Neurogenomics Unit, National Institute on Aging, Bethesda, MD, USA.ORCID 0000-0001-9358-8111 Andrew B SingletonCenter for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.ORCID 0000-0001-5606-700X Mina RytenAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.ORCID 0000-0001-9520-6957 Sonja W ScholzNeurodegenerative Diseases Research Unit, Laboratory of Neurogenetics, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.ORCID 0000-0002-6623-0429 Bryan J TraynorNeuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.ORCID 0000-0003-0527-2446 Nigel WilliamsInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff CF24 4HQ, UK.ORCID 0000-0003-1177-6931 Michele T M HuNuffield Department of Clinical Neurosciences, Division of Clinical Neurology, University of Oxford, Oxford OX3 9DU, UK.ORCID 0000-0001-6382-5841 Yoav Ben-ShlomoPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2PS, UK.ORCID 0000-0001-6648-3007 John HardyAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.ORCID 0000-0002-3122-0423 Huw R MorrisDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.ORCID 0000-0002-5473-3774 International LBD Genomic Consortium
National Hospital for Neurology and Neurosurgery · GBCardiff University · GBNational Institute on Aging · USJohns Hopkins University · USUniversity of Bristol · GBGreat Ormond Street Hospital · GBHong Kong University of Science and Technology · HKUK Dementia Research Institute · GBUniversity of Glasgow · GBUniversity of Oxford · GB
Funding
NINDS Biomarker RepositoryU24NS095871 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI TATIANA M. FOROUD · 2015 to 2026
$18.3MMedical Research Council MR/T018569/1NINDS NIH HHS U24 NS095871Parkinson's UK H-1703
6 · The paper itselfAbstract
Up to 80% of Parkinson's disease patients develop dementia, but time to dementia varies widely from motor symptom onset. Dementia with Lewy bodies presents with clinical features similar to Parkinson's disease dementia, but cognitive impairment precedes or coincides with motor onset. It remains controversial whether dementia with Lewy bodies and Parkinson's disease dementia are distinct conditions or represent part of a disease spectrum. The biological mechanisms underlying disease heterogeneity, in particular the development of dementia, remain poorly understood, but will likely be key to understanding disease pathways and ultimately therapy development. Previous genome-wide association studies in Parkinson's disease and dementia with Lewy bodies/Parkinson's disease dementia have identified risk loci differentiating patients from controls. We collated data for 7,804 patients of European ancestry from Tracking Parkinson's (PRoBaND), The Oxford Discovery Cohort, and AMP-PD. We conducted a discrete phenotype genome-wide association studies comparing Lewy body diseases with and without dementia to decode disease heterogeneity by investigating the genetic drivers of dementia in Lewy body diseases. We found that risk alleles rs429358 tagging
Indexed as
dementiagenome-wide association studiesLewy body diseases
Identifiers
PMID37987016
PMCPMC10659505
OpenAlexW4387736379
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390