ArticleResearch square2023
Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology.
Annie M Goettemoeller, Emmie Banks, Katharine E McCann, Prateek Kumar, Kelly South, Viktor J Olah, Christina C Ramelow, Duc M Duong, Nicholas T Seyfried, Srikant Rangaraju and 2 more
Abstract readPreprint
In one paragraphArticle in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
12 authors.
Emmie BanksDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA, 30322.
Katharine E McCannDepartment of Human Genetics, Emory University School of Medicine.
Prateek KumarDepartment of Neurology, Emory University School of Medicine.
Kelly SouthDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA, 30322.
Viktor J OlahDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA, 30322.
Christina C RamelowDepartment of Neurology, Emory University School of Medicine.
Duc M DuongDepartment of Neurology, Emory University School of Medicine.
Funding
Supplement to AMP-AD Brain Proteomic Network Enhancement, Validation and Translation into CSF BiomarkersU01AG061357 · NIA · EMORY UNIVERSITY · PI LEVEY, ALLAN I, SEYFRIED, NICHOLAS THOMAS · 2018 to 2022
$9.1MNeuron and microglia-specific proteomic signatures of ERK mediated mechanisms of Alzheimer’s diseaseR01AG075820 · NIA · YALE UNIVERSITY · PI RANGARAJU, SRIKANT, SEYFRIED, NICHOLAS THOMAS · 2021 to 2025
$5.1MTargeting Kv1.3 potassium channels for neuro-immunomodulation in Alzheimer's DiseaseR01NS114130 · NINDS · YALE UNIVERSITY · PI RANGARAJU, SRIKANT · 2020 to 2024
$3.1MAutomated cell-type-specific electrophysiology for understanding circuit dysregulation in Alzheimer's DiseaseRF1AG079269 · NIA · EMORY UNIVERSITY · PI FOREST, CRAIG, ROWAN, MATTHEW J.M. · 2022 to 2024
$2.4MMicroglia-specific proteomic mechanisms and biomarkers of neuroinflammation in Alzheimer’s diseaseRF1AG071587 · NIA · YALE UNIVERSITY · PI RANGARAJU, SRIKANT · 2021 to 2021
$2.1MNeuronal mechanisms of altered circuit excitability in early Alzheimer'sR56AG072473 · NIA · EMORY UNIVERSITY · PI ROWAN, MATTHEW J.M. · 2021 to 2021
$385kMechanism and restoration of altered firing in interneurons during early phase Alzheimer's DiseaseF31AG076289 · NIA · EMORY UNIVERSITY · PI GOETTEMOELLER, ANNIE M · 2022 to 2024
$143kInterneuron dysfunction and the emergence of tau pathology in early Alzheimer’s diseaseF31AG086006 · NIA · EMORY UNIVERSITY · PI BANKS, EMMIE · 2024 to 2025
$96kNIA NIH HHS F31 AG076289NIA NIH HHS F31 AG086006NIA NIH HHS R01 AG075820NIA NIH HHS R56 AG072473NIA NIH HHS RF1 AG071587NIA NIH HHS RF1 AG079269NIA NIH HHS U01 AG061357NINDS NIH HHS R01 NS114130
6 · The paper itselfAbstract
Preventative treatment for Alzheimer's Disease is of dire importance, and yet, cellular mechanisms underlying early regional vulnerability in Alzheimer's Disease remain unknown. In human patients with Alzheimer's Disease, one of the earliest observed pathophysiological correlates to cognitive decline is hyperexcitability
Indexed as
Alzheimer’s DiseaseAPPhyperexcitabilityinhibitionlateral entorhinal cortexPV interneuron
Identifiers
PMID37987015
PMCPMC10659529
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390