Evidence map›Paper›PMID 37987004›Full record

ArticlebioRxiv : the preprint server for biology2023

RNA structure modulates Cas13 activity and enables mismatch detection.

Ofer Kimchi, Benjamin B Larsen, Owen R S Dunkley, Aartjan J W Te Velthuis, Cameron Myhrvold

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Ofer KimchiLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, 08544, USA.ORCID 0000-0002-0801-0727
Benjamin B LarsenDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, 08544, USA.
Owen R S DunkleyDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, 08544, USA.
Aartjan J W Te VelthuisDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, 08544, USA.ORCID 0000-0002-5129-3953
Cameron MyhrvoldDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, 08544, USA.ORCID 0000-0002-8971-184X

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007388 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 1985 to 2022
$27.4M
Methods and Logic in Molecular Biology Training ProgramT32GM148739 · NIGMS · PRINCETON UNIVERSITY · PI Ileana M. Cristea · 2023 to 2026
$3.6M
Functional and genetic constraints on influenza virus replication and fidelityR01AI170520 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LAURING, ADAM · 2022 to 2025
$2.4M
Structure and dynamics of RNA elements regulating viral aberrant RNA synthesisDP2AI175474 · NIAID · PRINCETON UNIVERSITY · PI TE VELTHUIS, AREND JAN · 2022 to 2025
$2.4M
Development of a rapid multiplex CRISPR-based testing pathway for tuberculosis and COVID-19R21AI168808 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI BANADA, PADMAPRIYA, MYHRVOLD, CAMERON AMADEUS · 2022 to 2023
$438k
NIAID NIH HHS DP2 AI175474NIAID NIH HHS R01 AI170520NIAID NIH HHS R21 AI168808NIGMS NIH HHS T32 GM007388NIGMS NIH HHS T32 GM148739
6 · The paper itself

Abstract

The RNA-targeting CRISPR nuclease Cas13 has emerged as a powerful tool for applications ranging from nucleic acid detection to transcriptome engineering and RNA imaging

Indexed as

Cas13CRISPRRNA detectionRNA structurestrand displacement

Identifiers

PMID37987004
PMCPMC10659300

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.