Evidence map›Paper›PMID 37986976›Full record

ArticlebioRxiv : the preprint server for biology2023

Dengue virus exploits the host tRNA epitranscriptome to promote viral replication.

Cheryl Chan, Newman Siu Kwan Sze, Yuka Suzuki, Takayuki Ohira, Tsutomu Suzuki, Thomas J Begley, Peter C Dedon

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Cheryl ChanSingapore-MIT Alliance for Research and Technology, 1 CREATE Way, 138602, Singapore.
Newman Siu Kwan SzeSchool of Biological Sciences, Nanyang Technological University, Singapore 639798, Singapore.
Yuka SuzukiDepartment of Bioengineering, Graduate School of Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Takayuki OhiraDepartment of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Tsutomu SuzukiDepartment of Bioengineering, Graduate School of Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Thomas J BegleyDepartment of Biological Sciences and The RNA Institute, College of Arts and Science, University at Albany, SUNY, Albany, NY, 12222, USA.
Peter C DedonSingapore-MIT Alliance for Research and Technology, 1 CREATE Way, 138602, Singapore.ORCID 0000-0003-0011-3067
The University of Tokyo · JPCenter for Environmental Health · USNanyang Technological University · SGSingapore-MIT Alliance for Research and Technology · SGUniversity at Albany, State University of New York · US

Funding

Translational regulation in exposure biology: Xenobiotic-induced reprograming oftRNA modifications and selective translation of codon-biased response genes in rat and humanmodelsR01ES026856 · NIEHS · SUNY POLYTECHNIC INSTITUTE · PI Thomas J Begley, Peter C Dedon · 2016 to 2026
$3.9M
Translational Control of ROS ManagementR01ES024615 · NIEHS · SUNY POLYTECHNIC INSTITUTE · PI BEGLEY, THOMAS J · 2014 to 2018
$1.8M
NIEHS NIH HHS R01 ES024615NIEHS NIH HHS R01 ES026856
6 · The paper itself

Abstract

The 40-50 RNA modifications of the epitranscriptome regulate posttranscriptional gene expression. Here we show that flaviviruses hijack the host tRNA epitranscriptome to promote expression of pro-viral proteins, with tRNA-modifying ALKBH1 acting as a host restriction factor in dengue virus infection. Early in the infection of human Huh-7 cells, ALKBH1 and its tRNA products 5-formylcytidine (f

Identifiers

PMID37986976
PMCPMC10659268
OpenAlexW4388408171

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.