Evidence map›Paper›PMID 37986954›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Chronotropic Incompetence among People with HIV Improves with Exercise Training in the Exercise for Healthy Aging Study.

Matthew S Durstenfeld, Melissa P Wilson, Catherine M Jankowski, Grace L Ditzenberger, Chris T Longenecker, Kristine M Erlandson

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Matthew S DurstenfeldDivision of Cardiology at ZSFG and Department of Medicine, University of California, San Francisco (UCSF), USA.ORCID 0000-0002-7612-3352
Melissa P WilsonDepartment of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
Catherine M JankowskiCollege of Nursing, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0000-0003-0075-0023
Grace L DitzenbergerDepartment of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0000-0002-2318-3239
Chris T LongeneckerDivision of Cardiology and Department of Global Health, University of Washington Medical Center, Seattle, WA, USA.ORCID 0000-0002-9468-0179
Kristine M ErlandsonDepartment of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0000-0003-0808-6729
University of Colorado Anschutz Medical Campus · USUniversity of California, San Francisco · USUniversity of Washington Medical Center · US

Funding

UCSF Career Development Program in Cardiopulmonary, Hematologic, and Immunologic Comorbidities of HIV (CHIC)K12HL143961 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSUE, PRISCILLA Y., HUANG, LAURENCE · 2018 to 2022
$1.8M
The Impact of HIV and Aging on Physical Function and the Somatopause.K23AG050260 · NIA · UNIVERSITY OF COLORADO DENVER · PI ERLANDSON, KRISTINE MACE · 2014 to 2018
$946k
Mentoring Across Disciplines: Aging and Infectious Diseases with a Focus on MobilityK24AG082527 · NIA · UNIVERSITY OF COLORADO DENVER · PI Kristine Mace Erlandson · 2023 to 2026
$768k
NHLBI NIH HHS K12 HL143961NHLBI NIH HHS L30 HL159695NIA NIH HHS K23 AG050260NIA NIH HHS K24 AG082527
6 · The paper itself

Abstract

Background: People with HIV (PWH) have lower exercise capacity compared to HIV-uninfected peers, which may be explained by chronotropic incompetence (CI), the inability to increase heart rate during exercise. Methods: The Exercise for Healthy Aging Study included adults ages 50-75 with and without HIV. Participants completed 12 weeks of moderate intensity exercise, before randomization to moderate or high intensity for 12 additional weeks. We compared adjusted heart rate reserve (AHRR; CI <80%) on cardiopulmonary exercise testing by HIV serostatus, and change from baseline to 12 and 24 weeks using mixed effects models. Results: Among 32 PWH and 37 controls (median age 56, 7% female, mean BMI 28 kg/m Conclusions: Chronotropic incompetence contributes to reduced exercise capacity among PWH and improves with exercise training.

Indexed as

adjusted heart rate reserve/chronotropic indexcardiorespiratory fitnesschronotropic incompetenceexercise trainingHIVVO2

Identifiers

PMID37986954
PMCPMC10659453
OpenAlexW4388594128

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.