Evidence map›Paper›PMID 37986953›Full record

ArticlebioRxiv : the preprint server for biology2023

Neuronal PAS domain 1 identifies a major subpopulation of wakefulness-promoting GABAergic neurons in basal forebrain.

Timothy A Troppoli, Chun Yang, Fumi Katsuki, David S Uygun, Ilyan Lin, David Aguilar, Tristan Spratt, Radhika Basheer, James M McNally, C Savio Chan and 2 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Harvard University · USNorthwestern University · USWheaton College - Massachusetts · US

Funding

Striatopallidal GABAergic Signaling in Mouse Models of Parkinson's DiseaseR01NS069777 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHAN, SAVIO · 2010 to 2021
$3.9M
Neural Correlates of Sleep HomeostasisR01NS119227 · NINDS · HARVARD MEDICAL SCHOOL · PI BASHEER, RADHIKA · 2021 to 2025
$1.6M
Alteration of sleep and cortical parvalbumin interneurons in mouse model of Alzheimers diseaseK01AG068366 · NIA · HARVARD MEDICAL SCHOOL · PI KATSUKI, FUMI · 2021 to 2025
$607k
Investigation of Pallidal Neurons in Motor InhibitionR56NS069777 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHAN, SAVIO · 2022 to 2022
$536k
Subcortical influence on the respiratory coordination of cortical neurodynamicsrelated to cognitionR21MH125242 · NIMH · HARVARD MEDICAL SCHOOL · PI MCKENNA, JAMES TIMOTHY, MCNALLY, JAMES M · 2021 to 2022
$363k
Using CRISPR-Cas9 genetic abscission in vivo to study the role of GABA-A receptors of the thalamic reticular nucleus in regulating non-rapid-eye-movement sleep and drug induced sleepIK2BX004905 · VA · VA BOSTON HEALTH CARE SYSTEM · PI UYGUN, DAVID SAMUEL · 2020 to 2024
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Specification of sleep-wake control neurons in the basal forebrainI01BX004673 · VA · VA BOSTON HEALTH CARE SYSTEM · PI BROWN, RITCHIE EDWARD · 2020 to 2024
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Tuning cortical E/I balance for translational modeling of psychiatric disordersI01BX004500 · VA · VA BOSTON HEALTH CARE SYSTEM · PI JAMES M MCNALLY · 2019 to 2026
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BLRD VA I01 BX004500BLRD VA I01 BX004673BLRD VA IK2 BX004905NIA NIH HHS K01 AG068366NIMH NIH HHS R21 MH125242NINDS NIH HHS R01 NS069777NINDS NIH HHS R01 NS119227NINDS NIH HHS R56 NS069777
6 · The paper itself

Abstract

Here we describe a novel group of basal forebrain (BF) neurons expressing neuronal PAS domain 1 (Npas1), a developmental transcription factor linked to neuropsychiatric disorders. Immunohistochemical staining in Npas1-cre-2A-TdTomato mice revealed BF Npas1 SIGNIFICANCE STATEMENT: We characterize a group of basal forebrain (BF) neurons in the mouse expressing neuronal PAS domain 1 (Npas1), a developmental transcription factor linked to neuropsychiatric disorders. BF Npas1

Identifiers

PMID37986953
PMCPMC10659409
OpenAlexW4388593003

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.