ArticlemedRxiv : the preprint server for health sciences2023
Genome-Wide Interaction Analysis with DASH Diet Score Identified Novel Loci for Systolic Blood Pressure.
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Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 1 citations in OpenAlex.
- Evaluation of the performance of GPT-3.5 and GPT-4 on the Polish Medical Final Examination.Scientific reports · 2023Article
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Authors and funding
46 authors at 20 institutions in 6 countries.
Mélanie GuiretteFriedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.ORCID 0000-0002-8878-2224
Jessie LanFriedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
Nicola McKeownPrograms of Nutrition, Department of Health Sciences, Sargent College of Health & Rehabilitation Sciences, Boston University, Boston, MA, USA.
Michael R BrownHuman Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0002-5235-9037
Han ChenHuman Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0002-9510-4923
Paul S DE VriesHuman Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0003-0964-0111
Hyunju KimCardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, WA, USA.
Casey M RebholzDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-5442-8745
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0001-6381-4296
Traci M BartzCardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0003-3403-8763
Amanda M FrettsCardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-5358-2345
Xiuqing GuoThe Lundquist Institute at Harbor-UCLA, Torrance, CA, USA.ORCID 0000-0002-5264-5068
Rozenn N LemaitreCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-7038-1844
Ching-Ti LiuBiostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID 0000-0002-0703-0742
Raymond NoordamDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0001-7801-809X
Renée DE MutsertDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Frits R RosendaalDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0003-2558-7496
Carol A WangSchool of Medicine and Public Health, University of Newcastle, NSW, Australia.ORCID 0000-0002-4301-3974
Lawrence BeilinMedical School, Royal Perth Hospital Unit, University of Western Australia, Crawley, Western Australia, Australia.ORCID 0000-0003-4853-7360
Trevor A MoriMedical School, Royal Perth Hospital Unit, University of Western Australia, Crawley, Western Australia, Australia.ORCID 0000-0002-5264-9229
Wendy H OddyMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia Saw Swee Hock, School of Public Health, National University of Singapore and National University Health System, Singapore.
Craig E PennellSchool of Medicine and Public Health, University of Newcastle, NSW, Australia.ORCID 0000-0002-0937-6165
Jin Fang ChaiSchool of Population Health, Curtin University, Perth, Western Australia, Australia.
Clare WhittonSchool of Population Health, Curtin University, Perth, Western Australia, Australia.
Rob M VAN DamSchool of Population Health, Curtin University, Perth, Western Australia, Australia.ORCID 0000-0002-7354-8734
Jianjun LiuGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore.
E Shyong TaiSchool of Population Health, Curtin University, Perth, Western Australia, Australia.
Xueling SimSchool of Population Health, Curtin University, Perth, Western Australia, Australia.
Marian L NeuhouserDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Lesley TinkerDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Nora FranceschiniDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.ORCID 0009-0001-8346-3662
Tianxiao HuanFramingham Heart Study and Population Sciences Branch, NHLBI, Framingham, MA, USA.
Thomas W WinklerDepartment of Genetic Epidemiology, University of Regensburg; Regensburg, Germany.
Amy R BentleyCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
W James GaudermanDivision of Biostatistics, Department of Population and Public Health Sciences, University of Southern California; CA, USA.ORCID 0000-0002-6626-9091
Luc HeerkensDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, the Netherlands.ORCID 0000-0003-0460-7056
Toshiko TanakaLongitudinal Studies Section, National Institute on Aging, Baltimore, MD, USA.
Jeroen van RooijDepartment of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Patricia B MunroeCentre of Clinical Pharmacology & Precision Medicine, William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID 0000-0002-4176-2947
Helen R WarrenCentre of Clinical Pharmacology & Precision Medicine, William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID 0000-0003-0511-1386
Trudy VoortmanDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID 0000-0003-2830-6813
Honglei ChenDepartment of Epidemiology and Biostatistics College of Human Medicine, Michigan State University, East Lansing, Michigan, USA.
D C RaoCenter for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Daniel LevyFramingham Heart Study and Population Sciences Branch, NHLBI, Framingham, MA, USA.ORCID 0000-0003-1843-8724
Jiantao MaFriedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.ORCID 0000-0001-7478-7203
University of Washington · USCurtin University · AUFred Hutch Cancer Center · USLeiden University Medical Center · NLThe University of Texas Health Science Center at Houston · USTufts University · USAgency for Science, Technology and Research · SGBoston University · USErasmus MC · NLFramingham Heart Study · USHunter Medical Research Institute · AUMichigan State University · USQueen Mary University of London · GBThe University of Western Australia · AUJohns Hopkins University · USNational Institute on Aging · USNational Institutes of Health · USNational University Health System · SGNational University of Singapore · SGUCLA Medical Center · US
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MInstitute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4MFRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MEpidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8MExceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MRare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9MA Multi-Ancestry Study of Gene-Lifestyle Interactions and Multi-Omics in Cardiometabolic TraitsR01HL156991 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 2021 to 2024
$8.8MCARDIOVASCULAR HEALTH STUDY (CHS) - TASK AREA C, STUDY CLOSEOUT75N92021D00006 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE · 2021 to 2024
$8.4MA Multi-Ethnic Study of Gene-Lifestyle Interactions in Cardiovascular TraitsR01HL118305 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 2014 to 2017
$8.3MNCATS NIH HHS UL1 TR001881NCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004402NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS K22 HL135075NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL118305NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL156991NHLBI NIH HHS R01 HL163972NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS R01 AG023629NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK117445NIMHD NIH HHS R01 MD012765
Abstract
Objective: We examined interactions between genotype and a Dietary Approaches to Stop Hypertension (DASH) diet score in relation to systolic blood pressure (SBP). Methods: We analyzed up to 9,420,585 biallelic imputed single nucleotide polymorphisms (SNPs) in up to 127,282 individuals of six population groups (91% of European population) from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (CHARGE; n=35,660) and UK Biobank (n=91,622) and performed European population-specific and cross-population meta-analyses. Results: We identified three loci in European-specific analyses and an additional four loci in cross-population analyses at P for interaction < 5e-8. We observed a consistent interaction between rs117878928 at 15q25.1 (minor allele frequency = 0.03) and the DASH diet score (P for interaction = 4e-8; P for heterogeneity = 0.35) in European population, where the interaction effect size was 0.42±0.09 mm Hg (P for interaction = 9.4e-7) and 0.20±0.06 mm Hg (P for interaction = 0.001) in CHARGE and the UK Biobank, respectively. The 1 Mb region surrounding rs117878928 was enriched with Conclusion: We demonstrated gene-DASH diet score interaction effects on SBP in several loci. Studies with larger diverse populations are needed to validate our findings.
Indexed as
Association StudyCHARGE consortiumDASH DietGene Environment InteractionGenome-WideMTHFSST20Systolic PressureUK Biobank
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