Evidence map›Paper›PMID 37986935›Full record

ArticleResearch square2023

Neuronal Glycogen Breakdown Mitigates Tauopathy via Pentose Phosphate Pathway-Mediated Oxidative Stress Reduction.

Sudipta Bar, Kenneth A Wilson, Tyler A U Hilsabeck, Sydney Alderfer, Eric B Dammer, Jordan B Burton, Samah Shah, Anja Holtz, Enrique M Carrera, Jennifer N Beck and 7 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Sudipta BarBuck Institute for Research on Aging, Novato, CA 94947, USA.ORCID https://orcid.org/0000-0001-5591-8749
Kenneth A WilsonBuck Institute for Research on Aging, Novato, CA 94947, USA.ORCID https://orcid.org/0000-0003-3227-9977
Tyler A U HilsabeckBuck Institute for Research on Aging, Novato, CA 94947, USA.ORCID https://orcid.org/0000-0002-1690-4704
Sydney AlderferBuck Institute for Research on Aging, Novato, CA 94947, USA.
Eric B DammerEmory Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA.
Jordan B BurtonBuck Institute for Research on Aging, Novato, CA 94947, USA.ORCID https://orcid.org/0000-0002-5238-0872
Samah ShahBuck Institute for Research on Aging, Novato, CA 94947, USA.ORCID https://orcid.org/0000-0003-4688-1248
Anja HoltzBuck Institute for Research on Aging, Novato, CA 94947, USA.ORCID https://orcid.org/0000-0001-9856-002X
Enrique M CarreraBuck Institute for Research on Aging, Novato, CA 94947, USA.
Jennifer N BeckBuck Institute for Research on Aging, Novato, CA 94947, USA.ORCID https://orcid.org/0000-0003-0139-9271
Jackson H ChenBuck Institute for Research on Aging, Novato, CA 94947, USA.
Grant KauweBuck Institute for Research on Aging, Novato, CA 94947, USA.
Tara E TracyBuck Institute for Research on Aging, Novato, CA 94947, USA.
Nicholas T SeyfriedDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID https://orcid.org/0000-0002-4507-624X
Birgit SchillingBuck Institute for Research on Aging, Novato, CA 94947, USA.ORCID https://orcid.org/0000-0001-9907-2749
Lisa M EllerbyBuck Institute for Research on Aging, Novato, CA 94947, USA.
Pankaj KapahiBuck Institute for Research on Aging, Novato, CA 94947, USA.ORCID https://orcid.org/0000-0002-5629-4947
Buck Institute for Research on Aging · USEmory University · US

Funding

Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI Susan Lynn Stark · 2020 to 2026
$28.7M
Single cell analysis coreP01AG066591 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI MELOV, SIMON · 2021 to 2025
$15.5M
Training in Basic Research on Aging and Age-Related DiseaseT32AG000266 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Lisa M Ellerby · 1998 to 2026
$13.8M
Resilience pathways modeling human longevity-promoting ApoE variants in induced pluripotent stem cellsR01AG061879 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI ELLERBY, LISA M, MELOV, SIMON · 2018 to 2022
$4.4M
Impaired activity-dependent protein synthesis in dendrites and pathophysiology in tauopathyR01AG070193 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI TRACY, TARA · 2021 to 2025
$3.9M
Molecular Mechanisms of Lifespan Extension by Dietary Restriction in DrosophilaR01AG038688 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI KAPAHI, PANKAJ · 2011 to 2015
$2.3M
Role of Circadian Clocks in Aging using DrosophilaR01AG045835 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI KAPAHI, PANKAJ · 2013 to 2017
$2.1M
The role of natural genetic variants in nutrient-dependent changes in healthspan using D. melanogasterR21AG054121 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI BREM, RACHEL BETH, KAPAHI, PANKAJ · 2017 to 2018
$825k
TripleTOF 5600 High Resolution Mass SpectrometerS10OD016281 · OD · BUCK INSTITUTE FOR RESEARCH ON AGING · PI GIBSON, BRADFORD WAYNE · 2013 to 2013
$597k
GENETIC DISRUPTION OF TAU METABOLISM IN TAUOPATHIESK01AG046374 · NIA · WASHINGTON UNIVERSITY · PI KARCH, CELESTE MARIE · 2014 to 2018
$568k
NIA NIH HHS K01 AG046374NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P01 AG066591NIA NIH HHS P30 AG066444NIA NIH HHS R01 AG038688NIA NIH HHS R01 AG045835NIA NIH HHS R01 AG061879NIA NIH HHS R01 AG070193NIA NIH HHS R21 AG054121NIA NIH HHS T32 AG000266NIH HHS S10 OD016281
6 · The paper itself

Abstract

Tauopathies encompass a range of neurodegenerative disorders, such as Alzheimer's disease (AD) and frontotemporal dementia (FTD). Unfortunately, current treatment approaches for tauopathies have yielded limited success, underscoring the pressing need for novel therapeutic strategies. We observed distinct signatures of impaired glycogen metabolism in the

Identifiers

PMID37986935
PMCPMC10659530
OpenAlexW4388478426

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.