Evidence map›Paper›PMID 37986892›Full record

ArticlebioRxiv : the preprint server for biology2023

UV damage induces production of mitochondrial DNA fragments with specific length profiles.

Gus Waneka, Joseph Stewart, John R Anderson, Wentao Li, Jeffrey Wilusz, Juan Lucas Argueso, Daniel B Sloan

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Gus WanekaDepartment of Biology, Colorado State University, Fort Collins, Colorado, USA.
Joseph StewartDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado, USA.
John R AndersonDepartment of Microbiology, Immunology & Pathology, Colorado State University, Fort Collins, Colorado, USA.
Wentao LiDepartment of Environmental Health Science, University of Georgia, Athens, Georgia, USA.
Jeffrey WiluszDepartment of Microbiology, Immunology & Pathology, Colorado State University, Fort Collins, Colorado, USA.
Juan Lucas ArguesoDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado, USA.ORCID 0000-0002-7157-1519
Daniel B SloanDepartment of Biology, Colorado State University, Fort Collins, Colorado, USA.
Colorado State University · USUniversity of Georgia · US

Funding

MinION long-read DNA sequencer system for the analysis of structural genomic variation in yeastR35GM119788 · NIGMS · COLORADO STATE UNIVERSITY · PI ARGUESO, JUAN LUCAS · 2016 to 2025
$3.7M
Mechanisms of mitochondrial mutation rate variation across eukaryotesR35GM148134 · NIGMS · COLORADO STATE UNIVERSITY · PI Daniel Benjamin Sloan · 2023 to 2026
$1.7M
Role of Aflatoxin-induced DNA Damage Formation and Repair in Hepatic MutagenesisR00ES030015 · NIEHS · UNIVERSITY OF GEORGIA · PI LI, WENTAO · 2020 to 2022
$746k
NIEHS NIH HHS R00 ES030015NIGMS NIH HHS R35 GM119788NIGMS NIH HHS R35 GM148134
6 · The paper itself

Abstract

UV light is a potent mutagen that induces bulky DNA damage in the form of cyclobutane pyrimidine dimers (CPDs). In eukaryotic cells, photodamage and other bulky lesions occurring in nuclear genomes (nucDNAs) can be repaired through nucleotide excision repair (NER), where dual incisions on both sides of a damaged site precede the removal of a single-stranded oligonucleotide containing the damage. Mitochondrial genomes (mtDNAs) are also susceptible to damage from UV light, but current views hold that the only way to eliminate bulky DNA damage in mtDNAs is through mtDNA degradation. Damage-containing oligonucleotides excised during NER can be captured with anti-damage antibodies and sequenced (XR-seq) to produce high resolution maps of active repair locations following UV exposure. We analyzed previously published datasets from

Identifiers

PMID37986892
PMCPMC10659373
OpenAlexW4388590964

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.