Evidence map›Paper›PMID 37986890›Full record

ArticlebioRxiv : the preprint server for biology2023

Design of a symmetry-broken tetrahedral protein cage by a method of internal steric occlusion.

Nika Gladkov, Elena A Scott, Kyle Meador, Eric J Lee, Arthur D Laganowsky, Todd O Yeates, Roger Castells-Graells

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Nika GladkovDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, United States of America.
Elena A ScottDepartment of Chemistry, Texas A&M University, College Station, TX 77843, United States of America.ORCID 0009-0004-9122-1809
Kyle MeadorDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, United States of America.ORCID 0000-0001-5049-027X
Eric J LeeDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, United States of America.ORCID 0000-0003-3046-6859
Arthur D LaganowskyDepartment of Chemistry, Texas A&M University, College Station, TX 77843, United States of America.ORCID 0000-0001-5012-5547
Todd O YeatesDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, United States of America.ORCID 0000-0001-5709-9839
Roger Castells-GraellsUCLA-DOE Institute for Genomics and Proteomics, Los Angeles, CA 90095, United States of America.ORCID 0000-0002-3985-6194

Funding

Developing new tools to probe membrane protein-lipid interactions for biomedical applicationsR01GM139876 · NIGMS · TEXAS A&M UNIVERSITY · PI LAGANOWSKY, ARTHUR D · 2021 to 2024
$1.2M
NIGMS NIH HHS R01 GM139876
6 · The paper itself

Abstract

Methods in protein design have made it possible to create large and complex, self-assembling protein cages with diverse applications. These have largely been based on highly symmetric forms exemplified by the Platonic solids. Prospective applications of protein cages would be expanded by strategies for breaking the designed symmetry,

Indexed as

DARPinnanoparticlesprotein cagesProtein designsymmetry-breaking

Identifiers

PMID37986890
PMCPMC10659388

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.