Evidence map›Paper›PMID 37986888›Full record

ArticlebioRxiv : the preprint server for biology2023

Replication of [AT/TA]

Kara G Pytko, Rachel L Dannenberg, Kristin A Eckert, Mark Hedglin

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kara G PytkoDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802.
Rachel L DannenbergDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802.
Kristin A EckertDepartment of Pathology and Laboratory Medicine, The Jake Gittlen Laboratories for Cancer Research, Hershey, PA 17033.
Mark HedglinDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802.
Pennsylvania State University · USHershey (United States) · US

Funding

Pro-tumorigenic functions of human DNA polymerases eta and kappa during genome duplication under physiological replication stress conditionsR01CA237153 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI ECKERT, KRISTIN A · 2019 to 2023
$2.6M
NCI NIH HHS R01 CA237153
6 · The paper itself

Abstract

Difficult-to-Replicate Sequences (DiToRS) are natural impediments in the human genome that inhibit DNA replication under endogenous replication. Some of the most widely-studied DiToRS are A+T-rich, high "flexibility regions," including long stretches of perfect [AT/TA] microsatellite repeats that have the potential to collapse into hairpin structures when in single-stranded DNA (ssDNA) form and are sites of recurrent structural variation and double-stranded DNA (dsDNA) breaks. Currently, it is unclear how these flexibility regions impact DNA replication, greatly limiting our fundamental understanding of human genome stability. To investigate replication through flexibility regions, we utilized FRET to characterize the effects of the major ssDNA-binding complex, RPA, on the structure of perfect [AT/TA]

Indexed as

CFSDiToRSDNA polymerase δhairpinPCNARPA

Identifiers

PMID37986888
PMCPMC10659299
OpenAlexW4388508757

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.