Evidence map›Paper›PMID 37986882›Full record

ArticleResearch square2023

Exploiting Cooperative Pathogen Behavior for Enhanced Antibiotic Potency: A Trojan Horse Approach.

Alper Mutlu, Emily Vanderpool, Kendra P Rumbaugh, Stephen P Diggle, Ashleigh S Griffin

Abstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Alper MutluDepartmemt of Biology, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0003-4162-5966
Emily VanderpoolTexas Tech University Health Sciences Center, Lubbock, United States.
Kendra P RumbaughTexas Tech University Health Sciences Center, Lubbock, United States.ORCID https://orcid.org/0000-0002-7459-7001
Stephen P DiggleGeorgia Institute of Technology, Atlanta, United States.
Ashleigh S GriffinDepartmemt of Biology, University of Oxford, Oxford, United Kingdom.

Funding

Understanding in vivo antibiotic resistance in diverse Pseudomonas aeruginosa populationsR01AI153116 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI DIGGLE, STEPHEN PAUL · 2021 to 2025
$2.3M
NIAID NIH HHS R01 AI153116
6 · The paper itself

Abstract

Antimicrobial resistance poses an escalating global threat, rendering traditional drug development approaches increasingly ineffective. Thus, novel alternatives to antibiotic-based therapies are needed. Exploiting pathogen cooperation as a strategy for combating resistant infections has been proposed but lacks experimental validation. Empirical findings demonstrate the successful invasion of cooperating populations by non-cooperating cheats, effectively reducing virulence

Indexed as

Antimicrobial resistancecheatcooperationmicrobial social evolutionquorum sensingtrojan cheatvirulence

Identifiers

PMID37986882
PMCPMC10659551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.