Evidence map›Paper›PMID 37986821›Full record

ArticleResearch square2023

Pleiotrophin-Neuregulin1 promote axon regeneration and sorting in conduit repair of critical nerve gap injuries.

Xingjian Gu, Farial S Rahman, G Bendale, B Tran, J F Miyata, A Hernandez, S Anand, Mario I Romero-Ortega

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Xingjian GuDepartment of Biomedical Engineering, University of Houston, Houston TX 77204.ORCID https://orcid.org/0000-0001-6992-7646
Farial S RahmanDepartment of Biomedical Engineering, University of Houston, Houston TX 77204.ORCID https://orcid.org/0000-0003-3236-5082
G BendaleDepartment of Biomedical Engineering, University of Houston, Houston TX 77204.
B TranDepartment of Biomedical Engineering, University of Houston, Houston TX 77204.
J F MiyataDepartment of Biomedical Engineering, University of Houston, Houston TX 77204.
A HernandezDepartment of Biomedical Engineering, University of Houston, Houston TX 77204.
S AnandDepartment of Biomedical Engineering, University of Houston, Houston TX 77204.
Mario I Romero-OrtegaDepartment of Biomedical Engineering, University of Arizona, Tucson AZ 85721.
University of Houston · USUniversity of Arizona · USVirginia Commonwealth University · US

Funding

Long-Gap Nerve Regeneration by Pleiotrophic Support in Multiluminal GraftsR21NS072955 · NINDS · UNIVERSITY OF TEXAS ARLINGTON · PI ROMERO-ORTEGA, MARIO IGNACIO · 2011 to 2012
$391k
NINDS NIH HHS R21 NS072955
6 · The paper itself

Abstract

Significant challenges remain in the treatment of critical nerve gap injuries using artificial nerve conduits. We previously reported successful axon regeneration across a 40 mm nerve gap using a biosynthetic nerve implant (BNI) with multi-luminal synergistic growth factor release. However, axon sorting, remyelination, and functional recovery were limited. Neuregulin1 (NRG1) plays a significant role in regulating the proliferation and differentiation of Schwann cells (SCs) during development and after injury. We hypothesize that the release of NRG1 type III combined with pleiotrophin (PTN) in the BNI will enhance axon growth, remyelination, and function of regenerated nerves across a critical gap. A rabbit 40 mm peroneal gap injury model was used to investigate the therapeutic efficacy of BNIs containing either NRG1, PTN, or PTN+NRG1 growth factor release. We found that NRG1 treatment doubled the number of regenerated axons (1276±895) compared to empty controls (633±666) and PTN tripled this number (2270±989). NRG1 also significantly increased the number of SOX10

Indexed as

growth factornerve regenerationneuregulinradial sortingremyelinationSchwann cells

Identifiers

PMID37986821
PMCPMC10659554
OpenAlexW4388418933

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.