Evidence map›Paper›PMID 37986819›Full record

ArticlebioRxiv : the preprint server for biology2025

Cytoneme-mediated intercellular signaling in keratinocytes is essential for epidermal remodeling in zebrafish.

Yi Wang, Thomas Nguyen, Qingan He, Oliver Has, Kiarash Forouzesh, Dae Seok Eom

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yi WangDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA.
Thomas NguyenDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA.
Qingan HeDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA.
Oliver HasDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA.
Kiarash ForouzeshDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA.
Dae Seok EomDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA.ORCID 0000-0002-0617-8788
University of California, Irvine · US

Funding

UCI P30 Skin Center Systems Biology CoreP30AR075047 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ANDERSEN, BOGI, GANESAN, ANAND K · 2019 to 2025
$5.1M
Signaling at a distance mediated by vesicles on novel cellular protrusionsR35GM142791 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI EOM, DAE SEOK · 2021 to 2025
$1.9M
Interdisciplinary Training Program in Skin BiologyT32AR080622 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Bogi Andersen, Anand K Ganesan · 2022 to 2026
$909k
NIAMS NIH HHS P30 AR075047NIAMS NIH HHS T32 AR080622NIGMS NIH HHS R35 GM142791
6 · The paper itself

Abstract

The skin, the largest organ, functions as a primary defense mechanism. Epidermal stem cells supply undifferentiated keratinocytes that differentiate as they migrate toward the outermost skin layer. Although such a replenishment process is disrupted in various human skin diseases, its underlying mechanisms remain elusive. With high-resolution live imaging and in vivo manipulations, we revealed that Notch signaling between keratinocytes is mediated by signaling filopodia called cytonemes and is essential for proper keratinocyte differentiation and proliferation. Inhibiting keratinocyte cytonemes reduced Notch expression within undifferentiated keratinocytes, leading to abnormal differentiation and hyperproliferation, resembling human skin disease phenotypes. Overproduction of Interleukin (IL)-17 signal, associated with skin diseases like

Identifiers

PMID37986819
PMCPMC10659310
OpenAlexW4388610785

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.