Evidence map›Paper›PMID 37986804›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Expression of mitochondrial oxidative stress response genes in muscle is associated with mitochondrial respiration, physical performance, and muscle mass in the Study of Muscle, Mobility and Aging (SOMMA).

Gregory J Tranah, Haley N Barnes, Peggy M Cawthon, Paul M Coen, Karyn A Esser, Russell T Hepple, Zhiguang Huo, Philip A Kramer, Frederico G S Toledo, Daniel S Evans and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Gregory J TranahCalifornia Pacific Medical Center Research Institute, San Francisco, California, USA.
Haley N BarnesCalifornia Pacific Medical Center Research Institute, San Francisco, California, USA.
Peggy M CawthonCalifornia Pacific Medical Center Research Institute, San Francisco, California, USA.
Paul M CoenTranslational Research Institute, Advent Health, Orlando, Florida, USA.ORCID 0000-0002-2805-2115
Karyn A EsserDepartment of Physiology and Ageing, College of Medicine, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-5791-1441
Russell T HeppleDepartment of Physical Therapy, University of Florida, Gainesville, Florida, USA.
Zhiguang HuoDepartment of Biostatistics, College of Public Health & Health Professions, College of Medicine University of Florida, Gainesville, Florida, USA.
Philip A KramerDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Frederico G S ToledoDivision of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, USA.
Daniel S EvansCalifornia Pacific Medical Center Research Institute, San Francisco, California, USA.
Steven R CummingsCalifornia Pacific Medical Center Research Institute, San Francisco, California, USA.
University of California, San Francisco · USUniversity of Florida · USAdventHealth Orlando · USCalifornia Pacific Medical Center · USUniversity of Pittsburgh · USWake Forest University · US

Funding

Study of Muscle, Mobility and Aging: SOMMA2R01AG059416 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI STEVEN RON CUMMINGS, Peggy Mannen Cawthon · 2018 to 2026
$70.3M
Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamie Nicole Justice · 2002 to 2026
$36.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
NCATS NIH HHS UL1 TR001420NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG059416
6 · The paper itself

Abstract

Gene expression in skeletal muscle of older individuals may reflect compensatory adaptations in response to oxidative damage that preserve tissue integrity and maintain function. Identifying associations between oxidative stress response gene expression patterns and mitochondrial function, physical performance, and muscle mass in older individuals would further our knowledge of mechanisms related to managing molecular damage that may be targeted to preserve physical resilience. To characterize expression patterns of genes responsible for the oxidative stress response, RNA was extracted and sequenced from skeletal muscle biopsies collected from 575 participants (≥70 years old) from the Study of Muscle, Mobility and Aging. Expression levels of twenty-one protein coding RNAs related to the oxidative stress response were analyzed in relation to six phenotypic measures, including: maximal mitochondrial respiration from muscle biopsies (Max OXPHOS), physical performance (VO

Indexed as

AgingCohort StudyGene ExpressionMitochondriaMuscleOxidative Stress

Identifiers

PMID37986804
PMCPMC10659517
OpenAlexW4388406756

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.