Evidence map›Paper›PMID 37986789›Full record

ArticlebioRxiv : the preprint server for biology2024

Divergent reward cue representations in prefrontal cortex underlie differences in reward motivation between adolescents and adults.

Gabriela Manzano Nieves, Rachel M Rahn, Saba N Baskoylu, Conor M Liston

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Gabriela Manzano NievesDepartment of Psychiatry and Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-6989-4872
Rachel M RahnDepartment of Psychiatry and Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Saba N BaskoyluPicower Institute for Learning & Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Conor M ListonDepartment of Psychiatry and Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Cornell University · USMassachusetts Institute of Technology · US

Funding

Effects of early life stress on functional development of prefrontal-amygdala connectivityK00MH124183 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI MANZANO NIEVES, GABRIELA · 2020 to 2023
$309k
Implications of Prefrontal Cortex Development for Adolescent Reward Seeking BehaviorK99MH132082 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI MANZANO NIEVES, GABRIELA · 2023 to 2024
$225k
NIMH NIH HHS K00 MH124183NIMH NIH HHS K99 MH132082
6 · The paper itself

Abstract

A prevailing view on postnatal brain development is that brain regions gradually acquire adult functions as they mature. The medial prefrontal cortex (mPFC) regulates reward learning, motivation, and behavioral inhibition, and undergoes a protracted postnatal maturation. During adolescence, reward-seeking behavior is heightened compared to adulthood - a developmental difference that may be driven by a hypoactive mPFC, with decreased top-down control of impulsive reward-seeking. However, this hypothesis has been difficult to test directly, due in part to technical challenges of recording neuronal activity

Indexed as

2-Photon Calcium ImagingAdolescenceChemogeneticsDevelopmentMedial prefrontal cortexMotivationNeuronal DecodingReward Learning

Identifiers

PMID37986789
PMCPMC10659319
OpenAlexW4388538503

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.