ArticlebioRxiv : the preprint server for biology2024
Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific manner.
Anika Shimonty, Fabrizio Pin, Matt Prideaux, Gang Peng, Joshua R Huot, Hyeonwoo Kim, Clifford J Rosen, Bruce M Spiegelman, Lynda F Bonewald
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors at 4 institutions in 2 countries.
Anika ShimontyIndiana Center for Musculoskeletal Health, School of Medicine, Indiana University, IN, 46202, Indianapolis.
Fabrizio PinIndiana Center for Musculoskeletal Health, Department of Anatomy, School of Medicine, Indiana University, IN, 46202, Indianapolis.
Matt PrideauxIndiana Center for Musculoskeletal Health, Department of Anatomy, School of Medicine, Indiana University, IN, 46202, Indianapolis.ORCID 0000-0001-9211-9698 Gang PengIndiana Center for Musculoskeletal Health, Department of Medicine and Molecular Genetics, School of Medicine, Indiana University, IN, 46202, Indianapolis.ORCID 0000-0003-0307-9351 Joshua R HuotIndiana Center for Musculoskeletal Health, Department of Anatomy, School of Medicine, Indiana University, IN, 46202, Indianapolis.
Hyeonwoo KimDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.
Clifford J RosenMaine Medical Center Research Institute, ME, 04074, Scarborough, USA.
Bruce M SpiegelmanDepartment of Cancer Biology, Dana Farber Cancer Institute and Department of Cell Biology, Harvard University Medical School, MA, 02115, Boston, USA.
Lynda F BonewaldDepartment of Anatomy, Cell Biology and Physiology, Orthopaedic Surgery, School of Medicine, Indiana Center for Musculoskeletal Health, Indiana Center for Musculoskeletal Health, Indiana University, IN, 46202, Indianapolis.ORCID 0000-0002-5536-9943 Indiana University – Purdue University Indianapolis · USBoston University · USKorea Advanced Institute of Science and Technology · KRMaine Medical Center · US
Funding
Transgenic and Mechanical Loading CoreP01AG039355 · NIA · UNIVERSITY OF MISSOURI KANSAS CITY · PI BONEWALD, LYNDA F · 2012 to 2024
$19.3MNIA NIH HHS P01 AG039355
6 · The paper itselfAbstract
Irisin, released from exercised muscle, has been shown to have beneficial effects on numerous tissues but its effects on bone are unclear. We found significant sex and genotype differences in bone from wildtype (WT) mice compared to mice lacking
Identifiers
PMID37986762
PMCPMC10659274
OpenAlexW4388441512
What OpenQuestion holds
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LicenceCC BY-NC
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