ArticlemedRxiv : the preprint server for health sciences2023
Concurrent RB1 loss and
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Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
99 authors at 20 institutions in 11 countries.
Flurina A M SanerPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Kazuaki TakahashiPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Timothy BuddenSchool of Clinical Medicine, UNSW Medicine and Health, University of NSW Sydney, Sydney, New South Wales, Australia.
Ahwan PandeyPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Dinuka AriyaratnePeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Tibor A ZwimpferPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Nicola S MeagherSchool of Clinical Medicine, UNSW Medicine and Health, University of NSW Sydney, Sydney, New South Wales, Australia.
Sian FeredayPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Laura TwomeyPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Kathleen I PishasPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Therese HoangPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Adelyn BolithonSchool of Clinical Medicine, UNSW Medicine and Health, University of NSW Sydney, Sydney, New South Wales, Australia.
Nadia TraficantePeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Kathryn AlsopPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Elizabeth L ChristiePeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Eun-Young KangDepartment of Pathology and Laboratory Medicine, University of Calgary, Foothills Medical Center, Calgary, AB, Canada.
Gregg S NelsonDepartment of Oncology, Division of Gynecologic Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Prafull GhatageDepartment of Oncology, Division of Gynecologic Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Cheng-Han LeeDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.
Marjorie J RigganDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Duke University Medical Center, Durham, NC, USA.
Jennifer AlsopCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Matthias W BeckmannDepartment of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany.
Jessica BorosCentre for Cancer Research, The Westmead Institute for Medical Research, Sydney, New South Wales, Australia.
Alison H BrandDepartment of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia.
Angela Brooks-WilsonCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, Canada.
Michael E CarneyDepartment of Obstetrics and Gynecology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
Penny CoulsonDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Madeleine Courtney-BrooksDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Kara L Cushing-HaugenProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Cezary CybulskiDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
Mona A El-BahrawyDepartment of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital, London, UK.
Esther ElishaevDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Ramona ErberInstitute of Pathology, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany.
Simon A GaytherCenter for Bioinformatics and Functional Genomics and the Cedars Sinai Genomics Core, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Aleksandra Gentry-MaharajMRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, UK.
C Blake GilksDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Paul R HarnettThe University of Sydney, Sydney, New South Wales, Australia.
Holly R HarrisProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Arndt HartmannInstitute of Pathology, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany.
Alexander HeinDepartment of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany.
Joy HendleyPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
AOCS Group
Brenda Y HernandezUniversity of Hawaii Cancer Center, Honolulu, HI, USA.
Anna JakubowskaDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
Mercedes Jimenez-LinanDepartment of Histopathology, Addenbrooke's Hospital, Cambridge, UK.
Michael E JonesDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Scott H KaufmannDivision of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Catherine J KennedyCentre for Cancer Research, The Westmead Institute for Medical Research, Sydney, New South Wales, Australia.
Tomasz KluzDepartment of Gynecology and Obstetrics, Gynecology Oncology and Obstetrics, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszów, Poland.
Jennifer M KoziakAlberta Health Services-Cancer Care, Calgary, AB, Canada.
Björg KristjansdottirDepartment of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, Sweden.
Nhu D LeCancer Control Research, BC Cancer Agency, Vancouver, BC, Canada.
Marcin LenerInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, Szczecin, Poland.
Jenny LesterDavid Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, CA, USA.
Jan LubińskiDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
Constantina MateoiuDepartment of Pathology, University of Gothenburg, Gothenburg, Sweden.
Sandra OrsulicDavid Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, CA, USA.
Matthias RuebnerDepartment of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany.
Minouk J SchoemakerDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Mitul ShahCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Raghwa SharmaTissue Pathology and Diagnostic Oncology, Westmead Hospital, Sydney, New South Wales, Australia.
Mark E ShermanDepartment of Health Sciences Research, Mayo Clinic, Jacksonville, FL, USA.
Yurii B ShvetsovUniversity of Hawaii Cancer Center, Honolulu, HI, USA.
Naveena SinghDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
T Rinda SoongDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Helen SteedDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada.
Paniti SukumvanichDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Aline TalhoukBritish Columbia's Gynecological Cancer Research Team (OVCARE), University of British Columbia, BC Cancer, and Vancouver General Hospital, Vancouver, BC, Canada.
Sarah E TaylorDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Robert A VierkantDepartment of Quantitative Health Sciences, Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN, USA.
Chen WangDepartment of Quantitative Health Sciences, Division of Computational Biology, Mayo Clinic, Rochester, MN, USA.
Martin WidschwendterEUTOPS Institute, University of Innsbruck, Innsbruck, Austria.
Lynne R WilkensUniversity of Hawaii Cancer Center, Honolulu, HI, USA.
Stacey J WinhamDepartment of Quantitative Health Sciences, Division of Computational Biology, Mayo Clinic, Rochester, MN, USA.
Michael S AnglesioBritish Columbia's Gynecological Cancer Research Team (OVCARE), University of British Columbia, BC Cancer, and Vancouver General Hospital, Vancouver, BC, Canada.
Andrew BerchuckDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Duke University Medical Center, Durham, NC, USA.
James D BrentonCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Ian CampbellPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Linda S CookEpidemiology, School of Public Health, University of Colorado, Aurora, CO, USA.
Jennifer A DohertyHuntsman Cancer Institute, Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA.
Peter A FaschingDepartment of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany.
Renée T FortnerDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Marc T GoodmanCancer Prevention and Control Program, Cedars-Sinai Cancer, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Jacek GronwaldDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
David G HuntsmanDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Beth Y KarlanDavid Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, CA, USA.
Linda E KelemenDivision of Acute Disease Epidemiology, South Carolina Department of Health & Environmental Control, Columbia, SC, USA.
Usha MenonMRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, UK.
Francesmary ModugnoDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Paul D P PharoahCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Joellen M SchildkrautDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Karin SundfeldtDepartment of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, Sweden.
Anthony J SwerdlowDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Ellen L GoodeDepartment of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.
Anna DeFazioThe Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, New South Wales, Australia.
Martin KöbelDepartment of Pathology and Laboratory Medicine, University of Calgary, Foothills Medical Center, Calgary, AB, Canada.
Susan J RamusSchool of Clinical Medicine, UNSW Medicine and Health, University of NSW Sydney, Sydney, New South Wales, Australia.
David D L BowtellPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Dale W GarsedPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID 0000-0003-1223-0121
The University of Melbourne · AUUniversity of Pittsburgh · USPeter MacCallum Cancer Centre · AUThe University of Sydney · AUUniversitätsklinikum Erlangen · DEInternational Hereditary Cancer Center · PLMayo Clinic in Florida · USUniversity of British Columbia · CAUniversity of Calgary · CAUniversity of Hawaiʻi at Mānoa · USCedars-Sinai Medical Center · USInstitute of Cancer Research · GBUniversity of California, Los Angeles · USUniversity of Cambridge · GBUniversity of Gothenburg · SEAlberta Health Services · CACancer Institute of New South Wales · AUDuke Medical Center · USMRC Clinical Trials Unit at UCL · GBAddenbrooke's Hospital · GB
Funding
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MUniversity of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Pallav Pokhrel · 1996 to 2026
$56.2MUse of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI SCOTT H KAUFMANN · 2009 to 2026
$37.0MRelating Molecular Subgroups of Endometriosis-Associated Ovarian Cancers to Survival and RiskR01CA248288 · NCI · MAYO CLINIC ROCHESTER · PI Stacey J Winham · 2021 to 2026
$4.8MIdentifying Prognostic Markers and Therapeutic Targets for Serous Ovarian CancerR01CA172404 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RAMUS, SUSAN J · 2013 to 2017
$2.9MCancer Research UK 15601Cancer Research UK 22905Medical Research Council MC_UU_00004/01NCATS NIH HHS UL1 TR000124NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA071789NCI NIH HHS P50 CA136393NCI NIH HHS R01 CA172404NCI NIH HHS R01 CA248288
Abstract
Background: Somatic loss of the tumour suppressor RB1 is a common event in tubo-ovarian high-grade serous carcinoma (HGSC), which frequently co-occurs with alterations in homologous recombination DNA repair genes including Patients and methods: RB1 protein expression patterns were classified by immunohistochemistry in epithelial ovarian carcinomas of 7436 patients from 20 studies participating in the Ovarian Tumor Tissue Analysis consortium and assessed for associations with overall survival (OS), accounting for patient age at diagnosis and FIGO stage. We examined RB1 expression and germline Results: RB1 protein loss was most frequent in HGSC (16.4%) and was highly correlated with Conclusions: Co-occurrence of RB1 loss and
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