Evidence map›Paper›PMID 37986681›Full record

ArticleCancer medicine2023

Involvement of the OTUB1-YAP1 axis in driving malignant behaviors of head and neck squamous cell carcinoma.

Shengjian Jin, Takaaki Tsunematsu, Taigo Horiguchi, Yasuhiro Mouri, Wenhua Shao, Keiko Miyoshi, Hiroko Hagita, Motoharu Sarubo, Natsumi Fujiwara, Guangying Qi and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Shengjian JinDepartment of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Takaaki TsunematsuDepartment of Oral Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.ORCID 0000-0003-1043-2790
Taigo HoriguchiDepartment of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Yasuhiro MouriDepartment of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Wenhua ShaoDepartment of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Keiko MiyoshiDepartment of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Hiroko HagitaDepartment of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Motoharu SaruboDepartment of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Natsumi FujiwaraDepartment of Oral Healthcare Management, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Guangying QiGuangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, China.
Naozumi IshimaruDepartment of Oral Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Yasusei KudoDepartment of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.ORCID 0000-0002-0392-7720
Tokushima University · JPGuilin Medical University · CN

Funding

Japan Society for the Promotion of Science 21KK0162Japan Society for the Promotion of Science 22H03288Japan Society for the Promotion of Science 22K19629
6 · The paper itself

Abstract

backgroundComprehending the molecular mechanisms underlying head and neck squamous cell carcinoma (HNSCC) is vital for the development of effective treatment strategies. Deubiquitinating enzymes (DUBs), which regulate ubiquitin-dependent pathways, are potential targets for cancer therapy because of their structural advantages. Here we aimed to identify a potential target for HNSCC treatment among DUBs.

methodsA screening process was conducted using RNA sequencing data and clinical information from HNSCC patients in the TCGA database. A panel of 88 DUBs was analyzed to identify those associated with poor prognosis. Subsequently, HNSCC cells were modified to overexpress specific DUBs, and their effects on cell proliferation and invasion were evaluated. In vivo experiments were performed to validate the findings.

resultsIn HNSCC patients, USP10, USP14, OTUB1, and STAMBP among the screened DUBs were associated with a poor prognosis. Among them, OTUB1 showed the most aggressive characteristics in both in vitro and in vivo experiments. Additionally, OTUB1 regulated the stability and nuclear localization of YAP1, a substrate involved in cell proliferation and invasion. Notably, OTUB1 expression exhibited a positive correlation with the HNSCC-YAP score in HNSCC cells.

conclusionsThis study highlights the critical role of OTUB1 in HNSCC progression via modulating YAP1. Targeting the OTUB1-YAP1 axis holds promise as a potential therapeutic strategy for HNSCC treatment.

Indexed as

Deubiquitinating EnzymesHead and Neck NeoplasmsSquamous Cell Carcinoma of Head and NeckYAP-Signaling ProteinsCell Line, TumorHumansUbiquitin ThiolesteraseDeubiquitinating EnzymesOTUB1 protein, humanUbiquitin ThiolesteraseUSP10 protein, humanUSP14 protein, humanYAP-Signaling Proteinsdeubiquitinating enzyme (DUB)head and neck squamous cell carcinomainvasionOTUB1YAP

Identifiers

PMID37986681
PMCPMC10757095
OpenAlexW4388870508

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.