ArticleThe Journal of antimicrobial chemotherapy2024
Variation in antibiotic consumption in very preterm infants-a 10 year population-based study.
Article in The Journal of antimicrobial chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Azithromycin for Prevention of Bronchopulmonary Dysplasia and Other Neonatal Adverse Outcomes in Preterm Infants: An Updated Systematic Review and Meta-Analysis.Neonatology · 2026Pooled it
- The Goldilocks zone of optimal antimicrobial stewardship in preterm infants.Pediatric research · 2026Article
- Infant Mortality in Norway: A Population-Based Study From 2009 Through 2020.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- CoNS blood culture isolates from very preterm infants: antibiotic susceptibility, synergy testing andJAC-antimicrobial resistance · 2026Article
- Antibiotic exposure in culture-negative preterm infants: a 10-year single-centre study.Pediatric research · 2026Article
- Identifying Infants <32 Weeks' Gestation at Low Risk of Early-Onset Sepsis: A 10-Year Retrospective Study from Western Australia.Neonatology · 2026Article
- Outcomes and antimicrobial usage in preterm neonates < 34 weeks gestation with culture-negative neonatal sepsis: a prospective observational study.BMC infectious diseases · 2025Observational
- Sex differences in the blood metabolome of extremely preterm infants: a pilot study on the impact of antibiotic therapy.Biology of sex differences · 2025Article
- Current antibiotic and prophylactic antifungal drug policies in UK neonatal intensive care units: a national survey.JAC-antimicrobial resistance · 2025Article
- Absence of association between early antibiotic exposure and short-term adverse outcomes in very preterm infants: a single-center retrospective study.Frontiers in pediatrics · 2025Article
- A decade of neonatal sepsis in Stockholm, Sweden: Gram-positive pathogens were four times as common as Gram-negatives.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- Sustaining the Continued Effectiveness of an Antimicrobial Stewardship Program in Preterm Infants.Tropical medicine and infectious disease · 2024Article
- Pharmacokinetic and Pharmacodynamic Considerations of Antibiotic Use in Neonates.Antibiotics (Basel, Switzerland) · 2023Review
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Authors and funding
12 authors at 7 institutions in 1 country.
Funding
Abstract
objectivesWide variations in antibiotic use in very preterm infants have been reported across centres despite similar rates of infection. We describe 10 year trends in use of antibiotics and regional variations among very preterm infants in Norway. PATIENTS AND
methodsAll live-born very preterm infants (<32 weeks gestation) admitted to any neonatal unit in Norway during 2009-18 were included. Main outcomes were antibiotic consumption expressed as days of antibiotic therapy (DOT) per 1000 patient days (PD), regional variations in use across four health regions, rates of sepsis and sepsis-attributable mortality and trends of antibiotic use during the study period.
resultsWe included 5296 infants: 3646 (69%) were born at 28-31 weeks and 1650 (31%) were born before 28 weeks gestation with similar background characteristics across the four health regions. Overall, 80% of the very preterm infants received antibiotic therapy. The most commonly prescribed antibiotics were the combination of narrow-spectrum β-lactams and aminoglycosides, but between 2009 and 2018 we observed a marked reduction in their use from 100 to 40 DOT per 1000 PD (P < 0.001). In contrast, consumption of broad-spectrum β-lactams remained unchanged (P = 0.308). There were large variations in consumption of vancomycin, broad-spectrum β-lactams and first-generation cephalosporins, but no differences in sepsis-attributable mortality across regions.
conclusionsThe overall antibiotic consumption was reduced during the study period. Marked regional variations remained in consumption of broad-spectrum β-lactams and vancomycin, without association to sepsis-attributable mortality. Our results highlight the need for antibiotic stewardship strategies to reduce consumption of antibiotics that may enhance antibiotic resistance development.
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