ArticleJournal of intensive care2023
The optimal dose of mobilisation therapy in the ICU: a prospective cohort study.
Article in Journal of intensive care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03666286 (Prospective Registry of Mobilization-, Routine- and Outcome Data of Intensive Care Patients), which is not on this map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Registry of Mobilization-, Routine- and Outcome Data of Intensive Care Patients
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Neuromuscular electrical stimulation for early rehabilitation in critically ill patients: a systematic review of applied protocols.Critical care (London, England) · 2026Pooled it
- Guideline on positioning and early mobilisation in the critically ill by an expert panel.Intensive care medicine · 2024Guideline
- Dose-response relationship of early out-of-bed mobilization with functional decline and adverse events in patients after cardiovascular surgery requiring prolonged intensive care: a retrospective cohort study.Journal of intensive care · 2026Article
- Dose reporting and dose-stratified effects of early mobilization in mechanically ventilated adult ICU patients: a systematic review and meta-analysis.Frontiers in medicine · 2026Review
- Physical Therapist-Led Therapeutic Exercise and Mobility in Adult Intensive Care Units: A Scoping Review of Operational Definitions, Dose Progression, Safety, and Documentation.Journal of clinical medicine · 2025Review
- Effectiveness of rehabilitation dose heterogeneity for improving functional outcomes of patients with acute stroke: a nationwide observational study.Scientific reports · 2025Observational
- Timing of ceiling lift-assisted out-of-bed sitting training and outcomes in critically ill patients: a prospective cohort study.Critical care (London, England) · 2025Observational
- Personalizing ICU liberation for critically Ill children: shaping the future of the ABCDEF bundle.Current opinion in pediatrics · 2025Review
- Concurrent nutrition and physical rehabilitation interventions for patients with critical illness.Current opinion in clinical nutrition and metabolic care · 2025Review
- The impact of mobilization training time during the first postoperative week on the length of hospital stay in postoperative patients admitted to an intensive care unit.Journal of rehabilitation medicine · 2025Article
- Skeletal Muscle Mass Loss Leads to Prolonged Mechanical Ventilation and Higher Tracheotomy Rates in Critically Ill Patients.Journal of clinical medicine · 2024Article
- Evaluating optimal rehabilitation strategies in ICU: study protocol for a multicentre cohort study to assess Physical Activity dosing, Muscle mass, and physICal outcomeS (IPAMICS study).Annals of clinical epidemiology · 2024Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to assess the impact of duration of early mobilisation on survivors of critical illness. The hypothesis was that interventions lasting over 40 min, as per the German guideline, positively affect the functional status at ICU discharge.
methodsProspective single-centre cohort study conducted in two ICUs in Germany. In 684 critically ill patients surviving an ICU stay > 24 h, out-of-bed mobilisation of more than 40 min was evaluated.
resultsDaily mobilisation ≥ 40 min was identified as an independent predictor of an improved functional status upon ICU discharge. This effect on the primary outcome measure, change of Mobility-Barthel until ICU discharge, was observed in three different models for baseline patient characteristics (average treatment effect (ATE), all three models p < 0.001). When mobilisation parameters like level of mobilisation, were included in the analysis, the average treatment effect disappeared [ATE 1.0 (95% CI - 0.4 to 2.4), p = 0.16].
conclusionsA mobilisation duration of more than 40 min positively impacts functional outcomes at ICU discharge. However, the maximum level achieved during ICU stay was the most crucial factor regarding adequate dosage, as higher duration did not show an additional benefit in patients with already high mobilisation levels.
trial registrationProspective Registry of Mobilization-, Routine- and Outcome Data of Intensive Care Patients (MOBDB), NCT03666286. Registered 11 September 2018-retrospectively registered, https://classic. CLINICALTRIALS: gov/ct2/show/NCT03666286 .
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.