ArticleBehavioral and brain functions : BBF2023
Specific brain imaging alterations underlying autistic traits in children with attention-deficit/hyperactivity disorder.
Article in Behavioral and brain functions : BBF, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Autistic traits in children with ADHD: preliminary evidence for a subgroup with elevated rule-breaking and aggressive behaviors.BMC psychiatry · 2026Article
- Brain network characteristics and behavioral correlations in global developmental delay based on functional near-infrared spectroscopy.iScience · 2026Article
- Abnormal MRI Features in Children with ADHD: A Narrative Review of Large-Scale Studies.Brain sciences · 2026Review
- Altered attention and visuospatial abnormalities in Parkinson's disease: links to attention networks and basal ganglia.Frontiers in aging neuroscience · 2026Article
- Neurodevelopmental disorders in children: the role of MRI in early detection and intervention planning.Frontiers in neuroscience · 2026Review
- The relationship of sensory processing with ADHD and its co-occurring behavioural symptoms based on both undirected and directed network analysis.BMC psychiatry · 2025Article
- Performance of Autism Screening and Diagnostic Instruments Among Children with ADHD: A Systematic Review.Journal of autism and developmental disorders · 2025Article
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAutistic traits (ATs) are frequently reported in children with Attention-Deficit/Hyperactivity Disorder (ADHD). This study aimed to examine ATs in children with ADHD from both behavioral and neuroimaging perspectives.
methodsWe used the Autism Spectrum Screening Questionnaire (ASSQ) to assess and define subjects with and without ATs. For behavioral analyses, 67 children with ADHD and ATs (ADHD + ATs), 105 children with ADHD but without ATs (ADHD - ATs), and 44 typically developing healthy controls without ATs (HC - ATs) were recruited. We collected resting-state functional magnetic resonance imaging (rs-fMRI) data and analyzed the mean amplitude of low-frequency fluctuation (mALFF) values (an approach used to depict different spontaneous brain activities) in a sub-sample. The imaging features that were shared between ATs and ADHD symptoms or that were unique to one or the other set of symptoms were illustrated as a way to explore the "brain-behavior" relationship.
resultsCompared to ADHD-ATs, the ADHD + ATs group showed more global impairment in all aspects of autistic symptoms and higher hyperactivity/impulsivity (HI). Partial-correlation analysis indicated that HI was significantly positively correlated with all aspects of ATs in ADHD. Imaging analyses indicated that mALFF values in the left middle occipital gyrus (MOG), left parietal lobe (PL)/precuneus, and left middle temporal gyrus (MTG) might be specifically related to ADHD, while those in the right MTG might be more closely associated with ATs. Furthermore, altered mALFF in the right PL/precuneus correlated with both ADHD and ATs, albeit in diverse directions.
conclusionsThe co-occurrence of ATs in children with ADHD manifested as different behavioral characteristics and specific brain functional alterations. Assessing ATs in children with ADHD could help us understand the heterogeneity of ADHD, further explore its pathogenesis, and promote clinical interventions.
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