Evidence map›Paper›PMID 37985996›Full record

ArticleBMC medical informatics and decision making2023

Interpretable prediction of 3-year all-cause mortality in patients with chronic heart failure based on machine learning.

Chenggong Xu, Hongxia Li, Jianping Yang, Yunzhu Peng, Hongyan Cai, Jing Zhou, Wenyi Gu, Lixing Chen

Abstract read
In one paragraph

Article in BMC medical informatics and decision making, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Prognostic Models in Heart Failure: Hope or Hype?Journal of personalized medicine · 2025
    Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chenggong Xu *The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Hongxia Li *The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Jianping YangCollege of Big Data, Yunnan Agricultural University, Kunming, China.
Yunzhu PengThe First Affiliated Hospital of Kunming Medical University, Kunming, China.
Hongyan CaiThe First Affiliated Hospital of Kunming Medical University, Kunming, China.
Jing ZhouThe First Affiliated Hospital of Kunming Medical University, Kunming, China.
Wenyi GuThe First Affiliated Hospital of Kunming Medical University, Kunming, China.
Lixing ChenThe First Affiliated Hospital of Kunming Medical University, Kunming, China. ydyyclx@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe goal of this study was to assess the effectiveness of machine learning models and create an interpretable machine learning model that adequately explained 3-year all-cause mortality in patients with chronic heart failure.

methodsThe data in this paper were selected from patients with chronic heart failure who were hospitalized at the First Affiliated Hospital of Kunming Medical University, from 2017 to 2019 with cardiac function class III-IV. The dataset was explored using six different machine learning models, including logistic regression, naive Bayes, random forest classifier, extreme gradient boost, K-nearest neighbor, and decision tree. Finally, interpretable methods based on machine learning, such as SHAP value, permutation importance, and partial dependence plots, were used to estimate the 3-year all-cause mortality risk and produce individual interpretations of the model's conclusions.

resultIn this paper, random forest was identified as the optimal aools lgorithm for this dataset. We also incorporated relevant machine learning interpretable tand techniques to improve disease prognosis, including permutation importance, PDP plots and SHAP values for analysis. From this study, we can see that the number of hospitalizations, age, glomerular filtration rate, BNP, NYHA cardiac function classification, lymphocyte absolute value, serum albumin, hemoglobin, total cholesterol, pulmonary artery systolic pressure and so on were important for providing an optimal risk assessment and were important predictive factors of chronic heart failure.

conclusionThe machine learning-based cardiovascular risk models could be used to accurately assess and stratify the 3-year risk of all-cause mortality among CHF patients. Machine learning in combination with permutation importance, PDP plots, and the SHAP value could offer a clear explanation of individual risk prediction and give doctors an intuitive knowledge of the functions of important model components.

Indexed as

Heart FailureBayes TheoremChronic DiseaseCluster AnalysisHumansMachine LearningChronic heart failureMachine learningMortalityPartial dependence plotsPermutation importanceRandom forestSHAP value

Identifiers

PMID37985996
PMCPMC10662001

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.