Evidence map›Paper›PMID 37985972›Full record

ArticleBMC medical imaging2023

A novel MRI feature, the cut green pepper sign, can help differentiate a suprasellar pilocytic astrocytoma from an adamantinomatous craniopharyngioma.

Shumin Xu, Wanqun Yang, Yi Luo, Xiaoyu Wang, Yaowen Li, Xianlei Meng, Yuze Zhang, Hongwu Zeng, Biao Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Shumin XuDepartment of Radiology, Shenzhen Children's Hospital, Shenzhen, 518000, China.
Wanqun YangDepartment of Radiology, Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 514000, China.
Yi LuoDepartment of Radiology, Shenzhen Children's Hospital, Shenzhen, 518000, China.
Xiaoyu WangDepartment of Radiology, Shenzhen Children's Hospital, Shenzhen, 518000, China.
Yaowen LiDepartment of Radiology, Shenzhen Children's Hospital, Shenzhen, 518000, China.
Xianlei MengDepartment of Radiology, Shenzhen Children's Hospital, Shenzhen, 518000, China.
Yuze ZhangDepartment of Radiology, Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 514000, China.
Hongwu Zeng *Department of Radiology, Shenzhen Children's Hospital, Shenzhen, 518000, China. homerzeng@126.com.
Biao Huang *Department of Radiology, Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 514000, China. huangbiao@gdph.org.cn.
Shenzhen Children's Hospital · CNGuangdong Academy of Medical Sciences · CNGuangdong Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThere are no specific magnetic resonance imaging (MRI) features that distinguish pilocytic astrocytoma (PA) from adamantinomatous craniopharyngioma (ACP). In this study we compared the frequency of a novel enhancement characteristic on MRI (called the cut green pepper sign) in PA and ACP.

methodsConsecutive patients with PA (n = 24) and ACP (n = 36) in the suprasellar region were included in the analysis. The cut green pepper sign was evaluated on post-contrast T1WI images independently by 2 neuroradiologists who were unaware of the pathologic diagnosis. The frequency of cut green pepper sign in PA and ACP was compared with Fisher's exact test.

resultsThe cut green pepper sign was identified in 50% (12/24) of patients with PA, and 5.6% (2/36) with ACP. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the cut green pepper sign for diagnosing PA were 50%, 94.4%, 85.7% and 73.9%, respectively. There was a statistically significant difference in the age of patients with PA with and without the cut green pepper sign (12.3 ± 9.2 years vs. 5.5 ± 4.4 years, p = 0.035).

conclusionThe novel cut green pepper sign can help distinguish suprasellar PA from ACP on MRI.

Indexed as

AstrocytomaCapsicumCraniopharyngiomaPituitary NeoplasmsAdolescentAdultChildChild, PreschoolDiagnosis, DifferentialHumansMagnetic Resonance ImagingYoung AdultAdamantinomatous craniopharyngiomaCut green pepper signDifferential diagnosisMagnetic resonance imagingPilocytic astrocytoma

Identifiers

PMID37985972
PMCPMC10662486
OpenAlexW4388824132

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.