ArticleJournal of applied clinical medical physics2024
Incorporating variable RBE in IMPT optimization for ependymoma.
Article in Journal of applied clinical medical physics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Dynamic Proton arc therapy for paediatric parameningeal rhabdomyosarcoma.Journal of applied clinical medical physics · 2026Article
- Commissioning of a Monte Carlo-based scanning proton beam for breast cancer: Incorporating LETd calculations and variable RBE models.Journal of applied clinical medical physics · 2026Article
- Quantitative analysis of robustness-based versus LET-based optimization in intensity-modulated proton therapy for pediatric brain tumors.Journal of applied clinical medical physics · 2026Article
- Comparison of the effects of IMRT and IMPT on MRI features of normal brain tissue: a retrospective study.BMC medical imaging · 2025Article
- Beyond a constant proton relative biological effectiveness: A survey of clinical and research perspectives among proton institutions in Europe and the United States.Journal of applied clinical medical physics · 2025Article
- Cervical Cancer Tissue Analysis Using Photothermal Midinfrared Spectroscopic Imaging.Chemical & biomedical imaging · 2024Article
- Incorporating variable RBE in IMPT optimization for ependymoma.Journal of applied clinical medical physics · 2024Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo study the dosimetric impact of incorporating variable relative biological effectiveness (RBE) of protons in optimizing intensity-modulated proton therapy (IMPT) treatment plans and to compare it with conventional constant RBE optimization and linear energy transfer (LET)-based optimization.
methodsThis study included 10 pediatric ependymoma patients with challenging anatomical features for treatment planning. Four plans were generated for each patient according to different optimization strategies: (1) constant RBE optimization (ConstRBEopt) considering standard-of-care dose requirements; (2) LET optimization (LETopt) using a composite cost function simultaneously optimizing dose-averaged LET (LET
resultsWe found that the LETopt plans consistently achieved increased LET in tumor targets and similar or decreased LET in critical organs compared to other plans. On average, the VarRBEopt plans achieved lower mean and maximum doses with both constant and variable RBE in the brainstem and spinal cord for all 10 patients. To compensate for the underdosing of targets with 1.1 RBE for the VarRBEopt plans, the hRBEopt plans achieved higher physical dose in targets and reduced mean and especially maximum variable RBE doses compared to the ConstRBEopt and LETopt plans.
conclusionWe demonstrated the feasibility of directly incorporating variable RBE models in IMPT optimization. A hybrid RBE optimization strategy showed potential for clinical implementation by maintaining all current dose limits and reducing the incidence of high RBE in critical normal tissues in ependymoma patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.