ArticleCommunications biology2023
Elevated stress response marks deeply quiescent reserve cells of gastric chief cells.
Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Dissecting the differentiation origins of intestinal metaplasia and early intestinal-type gastric cancer in gastric antrum by single-cell RNA profiling.NPJ precision oncology · 2026Article
- Evidence that injury can causebioRxiv : the preprint server for biology · 2026Article
- scGGC: a two-stage strategy for single-cell clustering through cellular gene pathway construction.Briefings in bioinformatics · 2025Article
- scCCTR: An iterative selection-based semi-supervised clustering model for single-cell RNA-seq data.Computational and structural biotechnology journal · 2025Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Gastrointestinal tract organs harbor reserve cells, which are endowed with cellular plasticity and regenerate functional units in response to tissue damage. However, whether the reserve cells in gastrointestinal tract exist as long-term quiescent cells remain incompletely understood. In the present study, we systematically examine H2b-GFP label-retaining cells and identify a long-term slow-cycling population in the gastric corpus but not in other gastrointestinal organs. The label-retaining cells, which reside near the basal layers of the corpus, comprise a subpopulation of chief cells. The identified quiescent cells exhibit induction of Atf4 and its target genes including Atf3, a marker of paligenosis, and activation of the unfolded protein response, but do not show elevated expression of Troy, Lgr5, or Mist. External damage to the gastric mucosa induced by indomethacin treatment triggers proliferation of the quiescent Atf4
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