SynthesisNature genetics2023
Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications.
Open access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 7 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 7 pooled it
26.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 7 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Genome-wide association analyses of borderline personality disorder identify 11 loci and highlight shared risk with mental and somatic disorders.Nature genetics · 2026Pooled it
- Does illicit drug use increase stroke risk? A systematic review, meta-analyses, and Mendelian randomization analysis.International journal of stroke : official journal of the International Stroke Society · 2026Pooled it
- Genome-wide meta-analyses of cross substance use disorders in diverse populations.Molecular psychiatry · 2026Pooled it
- The genetics of cannabis lifetime use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Pooled it
- Multi-ancestry investigation of the genomics of erectile dysfunction.Nature communications · 2025Pooled it
- Challenges in interpreting Mendelian randomization studies with a disease as the exposure: Using COVID-19 liability studies as an exemplar.European journal of human genetics : EJHG · 2025Pooled it
- Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction.Nature communications · 2024Pooled it
- Convex approaches to isolate the shared and distinct genetic components of complex traits.Bioinformatics (Oxford, England) · 2026Article
- Cannabis and Psychosis: Genomic Methods Shed Light on Pathophysiological Processes.Biological psychiatry global open science · 2026Article
- Assessing measurement bias in substance use disorder criteria associated with childhood adversity and genetic liability.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026Article
- Genetic pleiotropy differentially linking brain variation to cannabis use and cannabis use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- The genetics of fibromyalgia and its relationships to psychiatric and medical traits.Nature communications · 2026Article
- Cross-ancestry genetic architecture reveals shared biological pathways of major psychiatric disorders.Molecular psychiatry · 2026Article
- Genetic Pathways Point to the Biology Underlying the Association Between Cannabis Use Disorder and Psychosis.Biological psychiatry global open science · 2026Article
- Mapping the genetic architecture of human cortical expansion and its links to neuropsychiatric disorders.bioRxiv : the preprint server for biology · 2026Article
- Review
- Dissecting the polygenic architecture of psychopathology via singular value decomposition of eight psychiatric genome-wide association studies and evaluation of component-based polygenic scores.General psychiatry · 2026Article
- Are polygenic scores for psychiatric and substance use outcomes "ready" for clinical application? Current state and next steps.Psychiatric genetics · 2026Review
- Utilizing multimodal cortical parcellations to identify novel regions of the human cerebral cortex associated with substance use disorders.Molecular psychiatry · 2026Article
- Polygenic risk factors for comorbid diagnoses in individuals with substance use disorders: A phenome-wide survival analysis.Psychological medicine · 2026Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors at 16 institutions in 6 countries.
Daniel F LeveyDivision of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. daniel.levey@yale.edu.ORCID 0000-0001-8431-9569
Marco GalimbertiDivision of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-6052-156X
Joseph D DeakDivision of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-0540-6080
Frank R WendtDivision of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Arjun BhattacharyaDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Dora KollerDivision of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-0415-0466
Kelly M HarringtonVA Boston Healthcare System, Massachusetts Veterans Epidemiology Research and Information Center, Boston, MA, USA.
Rachel QuadenVA Boston Healthcare System, Massachusetts Veterans Epidemiology Research and Information Center, Boston, MA, USA.
Emma C JohnsonDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0003-0394-777X
Priya GuptaDivision of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Mahantesh BiradarNIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.ORCID 0000-0002-4114-6255
Max LamResearch Division, Institute of Mental Health, Singapore, Singapore.ORCID 0000-0002-4256-7844
Megan CookeCenter for Addiction Medicine, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Veera M RajagopalDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-5236-168X
Stefany L L EmpkeDivision of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Hang ZhouDivision of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Yaira Z NunezDivision of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Henry R KranzlerMental Illness Research, Education and Clinical Center, Crescenz VAMC and Center for Studies of Addiction, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-1018-0450
Howard J EdenbergDepartments of Biochemistry and Molecular Biology and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0003-0344-9690
Arpana AgrawalDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-0313-793X
Jordan W SmollerPsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Todd LenczDepartment of Psychiatry and Molecular Medicine, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.ORCID 0000-0001-8586-338X
David M HougaardThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.ORCID 0000-0001-5928-3517
Anders D BørglumDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0001-8627-7219
Ditte DemontisDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0001-9124-2766
Veterans Affairs Million Veteran Program
J Michael GazianoHarvard Medical School, Boston, MA, USA.
Michael J GandalDepartments of Psychiatry and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-5800-5128
Renato PolimantiDivision of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-0745-6046
Murray B SteinPsychiatry Service, VA San Diego Healthcare System, San Diego, CA, USA.ORCID 0000-0001-9564-2871
Joel GelernterDivision of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. joel.gelernter@yale.edu.ORCID 0000-0002-4067-1859
Yale University · USAarhus University · DKBoston University · USBroad Institute · USHarvard University · USWashington University in St. Louis · USBrigham and Women's Hospital · USChildren's Hospital of Philadelphia · USHofstra University · USIndiana University School of MedicineMassachusetts General Hospital · USMoorfields Eye Hospital NHS Foundation Trust · GBStatens Serum Institut · DKThe University of Texas MD Anderson Cancer Center · USUniversity of Pennsylvania · USUniversity of Toronto · CA
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M2/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01MH124851 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BOERGLUM, ANDERS, DAVIS, LEA K · 2021 to 2025
$5.4MCognitive Genomics as a Window on Neurodevelopment and PsychopathologyR01MH117646 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI TODD LENCZ · 2018 to 2026
$4.7MIsoform-level probabilistic transcriptome-wide association to undercover neurogenetic mechanisms underlying complex psychiatric traitsR01MH121521 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GANDAL, MICHAEL · 2020 to 2024
$3.4M7/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01DA054869 · NIDA · WASHINGTON UNIVERSITY · PI AGRAWAL, ARPANA, EDENBERG, HOWARD J · 2021 to 2025
$3.3MPsycheMERGE: Leveraging electronic health records and genomics for mental health researchR01MH118233 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DAVIS, LEA K, SMOLLER, JORDAN W · 2019 to 2022
$3.1MPopulation-level and mechanistic dissection of 17q21 structural variant association with psychiatric traitsR01MH123922 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GANDAL, MICHAEL · 2020 to 2024
$3.1MInvestigating the Systems Genetics of the Patterns of Polysubstance Abuse and AddictionR33DA047527 · NIDA · YALE UNIVERSITY · PI POLIMANTI, RENATO · 2021 to 2023
$2.0MGenetics of Alcohol Dependence in African Americans: RecruitmentR01AA026364 · NIAAA · YALE UNIVERSITY · PI GELERNTER, JOEL · 2018 to 2022
$2.0MTranslational Alcohol Research Program (TARP)T32AA028259 · NIAAA · YALE UNIVERSITY · PI COSGROVE, KELLY P., VASILIOU, VASILIS · 2020 to 2024
$1.8MIdentifying genetic sources of comorbidity between cannabis and schizophrenia using genome-wide and integrative omics dataK01DA051759 · NIDA · WASHINGTON UNIVERSITY · PI JOHNSON, EMMA COVEY · 2021 to 2025
$816kGenome-wide Investigation of the Interplay Between Age-Related Hearing Loss and Smoking BehaviorsR21DC018098 · NIDCD · YALE UNIVERSITY · PI POLIMANTI, RENATO · 2019 to 2021
$440kBLRD VA I01 BX004820BLRD VA IK2 BX005058CSRD VA I01 CX001849NCATS NIH HHS UL1 TR001863NIAAA NIH HHS R01 AA026364NIAAA NIH HHS T32 AA028259NIDA NIH HHS K01 DA051759NIDA NIH HHS R01 DA054869NIDA NIH HHS R33 DA047527NIDCD NIH HHS R21 DC018098NIMH NIH HHS F32 MH122058NIMH NIH HHS R01 MH117646NIMH NIH HHS R01 MH118233NIMH NIH HHS R01 MH121521NIMH NIH HHS R01 MH123922NIMH NIH HHS R01 MH124851
Abstract
As recreational use of cannabis is being decriminalized in many places and medical use widely sanctioned, there are growing concerns about increases in cannabis use disorder (CanUD), which is associated with numerous medical comorbidities. Here we performed a genome-wide association study of CanUD in the Million Veteran Program (MVP), followed by meta-analysis in 1,054,365 individuals (n
Indexed as
Genome-Wide Association StudyMarijuana AbuseGenetic Predisposition to DiseaseHumansPolymorphism, Single NucleotidePublic HealthRacial GroupsVeterans
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.