ArticleScientific reports2023
Inhibition of ALDH2 by quercetin glucuronide suggests a new hypothesis to explain red wine headaches.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 17 citations in OpenAlex.
- Recent advances in alcohol metabolism: from the gut to the brain.Physiological reviews · 2025Review
- The Effect of Temperature and UV Manipulation on Anthocyanins, Flavonols, and Hydroxycinnamoyl-Tartrates in cv Nebbiolo Grapes (Plants (Basel, Switzerland) · 2024Article
- Advanced clinical symptoms of the antihangover compound HK-GCM-H01 in healthy Koreans.Translational and clinical pharmacology · 2024Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
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Abstract
The consumption of red wine induces headaches in some subjects who can drink other alcoholic beverages without suffering. The cause for this effect has been attributed to a number of components, often the high level of phenolics in red wine, but a mechanism has been elusive. Some alcohol consumers exhibit flushing and experience headaches, and this is attributed to a dysfunctional ALDH2 variant, the enzyme that metabolizes acetaldehyde, allowing it to accumulate. Red wine contains much higher levels of quercetin and its glycosides than white wine or other alcoholic beverages. We show that quercetin-3-glucuronide, a typical circulating quercetin metabolite, inhibits ALDH2 with an IC
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