Evidence map›Paper›PMID 37985666›Full record

ArticleScientific data2023

Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases.

McKinzie A Garrison, Yeongjun Jang, Taejeong Bae, Adriana Cherskov, Sarah B Emery, Liana Fasching, Attila Jones, John B Moldovan, Cindy Molitor, Sirisha Pochareddy and 21 more

Open access · goldAbstract readDataset
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific data, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 19 institutions in 2 countries.

McKinzie A GarrisonProgram in Biochemistry, Molecular and Cellular Biology, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.ORCID 0000-0002-9949-4164
Yeongjun JangDepartment of Quantitative Health Sciences, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, 55905, USA.ORCID 0000-0002-7816-3278
Taejeong BaeDepartment of Quantitative Health Sciences, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, 55905, USA.ORCID 0000-0002-4626-3725
Adriana CherskovDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, 06520, USA.
Sarah B EmeryDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Liana FaschingChild Study Center, Yale University, New Haven, CT, 06520, USA.
Attila JonesDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.ORCID 0000-0003-0257-8781
John B MoldovanDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Cindy MolitorSage Bionetworks, 2901 Third Ave., Suite 330, Seattle, WA, 98121, USA.
Sirisha PochareddyDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, 06520, USA.
Mette A PetersSage Bionetworks, 2901 Third Ave., Suite 330, Seattle, WA, 98121, USA.
Joo Heon ShinLieber Institute for Brain Development, Baltimore, MD, 21205, USA.ORCID 0000-0002-5563-8605
Yifan WangDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Xiaoxu YangRady Children's Institute for Genomic Medicine, 7910 Frost St., Suite #300, San Diego, CA, 92123, USA.ORCID 0000-0003-0219-0023
Schahram AkbarianFriedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-7700-0891
Andrew ChessDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Fred H GageLaboratory of Genetics LOG-G, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.ORCID 0000-0002-0938-4106
Joseph G GleesonRady Children's Institute for Genomic Medicine, 7910 Frost St., Suite #300, San Diego, CA, 92123, USA.
Jeffrey M KiddDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-9631-1465
Michael McConnellLieber Institute for Brain Development, Baltimore, MD, 21205, USA.ORCID 0000-0001-6196-0791
Ryan E MillsDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
John V MoranDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-5308-4864
Peter J ParkDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-9378-960X
Nenad SestanDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, 06520, USA.ORCID 0000-0003-0966-9619
Alexander E UrbanDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, 94305, USA.ORCID 0000-0001-9772-933X
Flora M VaccarinoDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, 06520, USA.ORCID 0000-0003-2167-981X
Christopher A WalshDivision of Genetics and Genomics and Howard Hughes Medical Institute, Boston Children's Hospital, Departments of Pediatrics and Neurology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0156-2238
Daniel R WeinbergerLieber Institute for Brain Development, Baltimore, MD, 21205, USA.ORCID 0000-0003-2409-2969
Sarah J WheelanDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alexej AbyzovDepartment of Quantitative Health Sciences, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, 55905, USA. Abyzov.Alexej@mayo.edu.ORCID 0000-0001-5405-6729
BSMN Consortium
Boston Children's Hospital · USUniversity of Michigan · USHarvard University · USUniversitat Pompeu Fabra · ESYale University · USLieber Institute for Brain Development · USChildren’s Institute · USJohns Hopkins University · USSalk Institute for Biological Studies · USStanford University · USMayo Clinic · USSage Bionetworks · USAllen Institute for Brain Science · USIcahn School of Medicine at Mount Sinai · USKennedy Krieger Institute · USUniversity of California San Diego · USUniversitat de Barcelona · ESUniversity of California, Los Angeles · USUniversity of Massachusetts Chan Medical School · US

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
1/2-Somatic mosaicism and autism spectrum disorderU01MH106883 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI PARK, PETER J, WALSH, CHRISTOPHER A. · 2015 to 2019
$9.2M
Somatic Mosaicism in Schizophrenia and Control BrainsU01MH106891 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AKBARIAN, SCHAHRAM, CHESS, ANDREW J · 2015 to 2019
$7.3M
Somatic Mosaicism in the Brain of Tourette SyndromeU01MH106876 · NIMH · YALE UNIVERSITY · PI VACCARINO, FLORA M · 2015 to 2019
$6.1M
3/3-Schizophrenia Genetics and Brain Somatic MosaicismU01MH106882 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI GAGE, FRED H · 2015 to 2019
$5.3M
Mosaicism in focal cortical dysplasias spectrum seen in neuropsychiatric diseaseU01MH108898 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G · 2015 to 2019
$5.1M
2/3 Schizophrenia Genetics and Brain Somatic MosaicismU01MH106892 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORAN, JOHN V. · 2015 to 2019
$4.7M
2/2 Somatic mosaicism and autism spectrum disorderU01MH106874 · NIMH · YALE UNIVERSITY · PI SESTAN, NENAD · 2015 to 2019
$4.0M
BSMN Reference Tissue Project (Lieber Institute for Brain Development) 1U01MH106893-01 - 1/3-Schizophrenia Genetics and Brain Somatic MosaicismU01MH106893 · NIMH · LIEBER INSTITUTE, INC. · PI WEINBERGER, DANIEL · 2015 to 2019
$3.9M
Role of somatic mosaicism in autism, schizophrenia, and bipolar disorder brainU01MH106884 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI PEVSNER, JONATHAN · 2015 to 2019
$2.5M
Origins of Brain Somatic Mosaicism in Developmental Brain DiseaseR01MH124890 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G · 2021 to 2025
$1.5M
Mechanisms controlling HIV latency and pathogenesis in microgliaR21MH134401 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHLACHETZKI, JOHANNES CAROLUS MAGNUS, YANG, XIAOXU · 2023 to 2023
$435k
NICHD NIH HHS K99 HD111686NIGMS NIH HHS T32 GM007445NIMH NIH HHS R01 MH124890NIMH NIH HHS R21 MH134401NIMH NIH HHS U01 MH106874NIMH NIH HHS U01 MH106876NIMH NIH HHS U01 MH106882NIMH NIH HHS U01 MH106883NIMH NIH HHS U01 MH106884NIMH NIH HHS U01 MH106891NIMH NIH HHS U01 MH106892NIMH NIH HHS U01 MH106893NIMH NIH HHS U01 MH108898
6 · The paper itself

Abstract

Somatic mosaicism is defined as an occurrence of two or more populations of cells having genomic sequences differing at given loci in an individual who is derived from a single zygote. It is a characteristic of multicellular organisms that plays a crucial role in normal development and disease. To study the nature and extent of somatic mosaicism in autism spectrum disorder, bipolar disorder, focal cortical dysplasia, schizophrenia, and Tourette syndrome, a multi-institutional consortium called the Brain Somatic Mosaicism Network (BSMN) was formed through the National Institute of Mental Health (NIMH). In addition to genomic data of affected and neurotypical brains, the BSMN also developed and validated a best practices somatic single nucleotide variant calling workflow through the analysis of reference brain tissue. These resources, which include >400 terabytes of data from 1087 subjects, are now available to the research community via the NIMH Data Archive (NDA) and are described here.

Indexed as

Mental DisordersAutism Spectrum DisorderBrainGenome, HumanGenomicsHumansMosaicism

Identifiers

PMID37985666
PMCPMC10662356
OpenAlexW4388823873

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.