ArticleCardiovascular engineering and technology2024
On the Material Constitutive Behavior of the Aortic Root in Patients with Transcatheter Aortic Valve Implantation.
Article in Cardiovascular engineering and technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Fully coupled patient-specific fluid-structure interaction modeling of post-TAVI hemodynamics compared with echocardiographic measurements.Biomechanics and modeling in mechanobiology · 2026Article
- An In Silico Patient-Specific Computational Framework for a Tissue-Engineered Pulmonary Valve Using Fluid-Structure Interaction Analysis.Annals of biomedical engineering · 2026Article
- Credibility assessment of patient-specific modeling in transcatheter aortic valve implantation. I. A population-based validation of patient-specific modeling.APL bioengineering · 2025Article
- Credibility assessment of patient-specific modeling in transcatheter aortic valve implantation-Part 2: Uncertainty quantification and sensitivity analysis.APL bioengineering · 2025Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundTranscatheter aortic valve implantation (TAVI) is a minimally invasive procedure used to treat patients with severe aortic valve stenosis. However, there is limited knowledge on the material properties of the aortic root in TAVI patients, and this can impact the credibility of computer simulations. This study aimed to develop a non-invasive inverse approach for estimating reliable material constituents for the aortic root and calcified valve leaflets in patients undergoing TAVI.
methodsThe identification of material parameters is based on the simultaneous minimization of two cost functions, which define the difference between model predictions and cardiac-gated CT measurements of the aortic wall and valve orifice area. Validation of the inverse analysis output was performed comparing the numerical predictions with actual CT shapes and post-TAVI measures of implanted device diameter.
resultsA good agreement of the peak systolic shape of the aortic wall was found between simulations and imaging, with similarity index in the range in the range of 83.7% to 91.5% for n.20 patients. Not any statistical difference was observed between predictions and CT measures of orifice area for the stenotic aortic valve. After TAVI simulations, the measurements of SAPIEN 3 Ultra (S3) device diameter were in agreement with those from post-TAVI angio-CT imaging. A sensitivity analysis demonstrated a modest impact on the S3 diameters when altering the elastic material property of the aortic wall in the range of inverse analysis solution.
conclusionsOverall, this study demonstrates the feasibility and potential benefits of using non-invasive imaging techniques and computational modeling to estimate material properties in patients undergoing TAVI.
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