Evidence map›Paper›PMID 37985514›Full record

ArticleHerz2024

Urantide alleviates atherosclerosis-related liver and kidney injury via the Wnt/β-catenin signaling pathway in ApoE(-/-) mice.

Yu-Hang Xu, Jia-Yi Xie, Shen Huang, Tu Wang, Hai-Peng Cui, Juan Zhao

Abstract read
PubMed Publisher
In one paragraph

Article in Herz, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yu-Hang XuDepartment of Pathophysiology, Chengde Medical University, Anyuan Road, 067000, Chengde, Hebei, China.
Jia-Yi XieDepartment of Pathophysiology, Chengde Medical University, Anyuan Road, 067000, Chengde, Hebei, China.
Shen HuangDepartment of Pathophysiology, Chengde Medical University, Anyuan Road, 067000, Chengde, Hebei, China.
Tu WangDepartment of Pathophysiology, Chengde Medical University, Anyuan Road, 067000, Chengde, Hebei, China.
Hai-Peng CuiDepartment of Pathophysiology, Chengde Medical University, Anyuan Road, 067000, Chengde, Hebei, China.
Juan ZhaoDepartment of Pathophysiology, Chengde Medical University, Anyuan Road, 067000, Chengde, Hebei, China. zhaojuan_profdr@163.com.
Chengde Medical University · CN

Funding

Basic Research Funds for Chengde Medical College in 2022 KY202227Chengde Medical College National Natural Science Foundation Project Cultivation Fund and Key Subjects (Pathology and Pathophysiology) at Colleges and Universities of Hebei Province grant no. 201916Hebei Provincial Department of Education Outstanding Youth Fund Project grant no. YQ2013005Hebei Provincial Natural Science Foundation grant no. H2020406011Hebei Provincial Party Committee Organization Department Youth Top Talent Project grant no. JZZ (2016) No. 9Hebei Provincial Science and Technology Department Science and Technology Innovation Guidance Special Project, Hebei Provincial Department of Education Key Project grant no. ZD2019098Natural Science Foundation for Youth of Chengde Medical College Cultivation Fund KY202123
6 · The paper itself

Abstract

objectiveTo investigate the role of urantide in the prevention and treatment of atherosclerosis (AS)-related liver and kidney injury by antagonizing the urotensin II/urotensin receptor (UII/UT) system and regulating the Wnt/β-catenin signaling pathway.

methodsAtherosclerotic ApoE

resultsWhen ApoE

conclusionUrantide could improve AS-related liver and kidney injury by antagonizing the UII/UT system, and the improvements in liver and kidney function in atherosclerotic ApoE

Indexed as

AtherosclerosisWnt Signaling PathwayAnimalsApolipoproteins EDisease Models, AnimalMaleMiceMice, KnockoutPeptide FragmentsTreatment OutcomeUrotensinsApolipoproteins EPeptide Fragmentsurotensin II (4-11), Pen(5)-Trp(7)-Orn(8)-UrotensinsAtherosclerosisG‑protein-coupled receptor 14Kidney injuryLiver injuryUrantideUrotensin IIWnt/β-catenin pathway

Identifiers

PMID37985514
OpenAlexW4388824068

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.