Evidence map›Paper›PMID 37985486›Full record

ArticleJournal of neurology2024

Dietary inflammatory index, genetic susceptibility and risk of incident dementia: a prospective cohort study from UK biobank.

Min Peng, Shiqi Yuan, Dan Lu, Yitong Ling, Xiaxuan Huang, Jun Lyu, Anding Xu

Abstract read
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In one paragraph

Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

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  9. Mechanisms of comorbidity between Alzheimer's disease and pain.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Min Peng *Department of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Shiqi Yuan *Department of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Dan Lu *Department of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Yitong LingDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Xiaxuan HuangDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Jun LyuDepartment of Clinical Research, The First Affiliated Hospital of Jinan University, Guangzhou, China. lyujun2020@jnu.edu.cn.
Anding XuDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, China. tlil@jnu.edu.cn.ORCID http://orcid.org/0000-0003-3154-0985
First Affiliated Hospital of Jinan University · CNGuangdong Provincial Hospital of Traditional Chinese Medicine · CN

Funding

Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization Grant No. 2021B1212040007Natural Science Foundation of Guangdong Province 2018A0303130182Natural Science Foundation of Guangdong Province 2020A1515010279Science and Technology Program of Guangzhou, China 2014Y2-00505Science and Technology Program of Guangzhou, China 201508020004Science and Technology Program of Guangzhou-Key Lab of Guangzhou Basic and Translational Research of Pan-vascular Diseases 202201020042the Basic and Applied Basic Research Fund Project of Guangdong Province 2022A1515012311the Fundamental Research Funds for the Central Universities 21621102the National Natural Science Foundation of China 81671167the National Natural Science Foundation of China 81801150the National Natural Science Foundation of China 81971121the National Natural Science Foundation of China 82171316the National Natural Science Foundation of China 82271304the Science and Technology Planning Project of Guangdong Province 2017A020215049the Science and Technology Planning Project of Guangdong Province 2019A050513005the Science and Technology Planning Project of Guangzhou 202002020003the Science and Technology Planning Project of Guangzhou 202201010127
6 · The paper itself

Abstract

backgroundGenetic factors, diet and inflammation are associated with the development of dementia. In this study, we aimed at evaluating the impact of the dietary inflammatory index (DII) scores and genetic susceptibility on the development of dementia.

methodsThis prospective study involved 207,301 participants aged between 39 and 72 years from UK biobank. A web-based 24-h dietary questionnaire was collected at least once from participants between 2006 and 2012. The DII was calculated based on inflammatory effect score of nutrients. Individual AD-GRS (Alzheimer's disease genetic risk score) was calculated. Incident dementia was ascertained through hospital or death records.

resultsOf all 207,301 participants, 468 incident cases of all-cause dementia (165 AD, 91 VD and 26 FTD) were reported during a follow-up period of 11.4 years. The participants in the highest quintile (Q) of DII scores reported a higher risk for all-cause dementia (Q5 vs. Q3, hazard ratio (HR) = 1.702; 95% CI: 1.285-2.255) and VD (Q5 vs. Q3, HR = 2.266, 95% CI: 1.133-4.531) compared to participants in the Q3. Besides, when compared with the Q1, there was a higher risk for AD in the subjects of Q5 (Q5 vs. Q1, HR = 1.590; 95% CI: 1.004-2.519). There was a non-linear relationship between DII score and all-cause incidence (P for non-linear = 0.038) by restricted cubic splines. Subgroup analysis found that the increased risk for all-cause dementia and AD was more pronounced in the elderly, women, and higher educated population. Cox regression models indicated that compared with the participants who had a low AD-GRS risk and in the lowest tertile of DII, participants had a high AD-GRS and the highest tertile of DII were associated with a higher risk of AD (HR = 1.757, 95% CI: 1.082-2.855, P = 0.023).

conclusionsThe DII scores were independently associated with an augmented risk for all-cause dementia, AD and VD. Additionally, high AD-GRS with higher DII scores was significantly associated with a higher risk of AD.

Indexed as

Alzheimer DiseaseUK BiobankAdultAgedBiological Specimen BanksDietFemaleFollow-Up StudiesGenetic Predisposition to DiseaseHumansInflammationMiddle AgedProspective StudiesRisk FactorsAlzheimer’s diseaseDementiaDietary inflammatory indexUK biobank

Identifiers

PMID37985486
OpenAlexW4388823232

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.