ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease.
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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15citing papers in PubMed
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15 citing papers in PubMed.
- Genetically linked brain imaging markers of memory decline in aging and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Mitochondrial Dynamics and SLC25 Transporters in Neurodegeneration: From Mechanisms to Therapeutic Opportunities.Biomolecules · 2026Review
- Contributions of the Alzheimer's Disease Neuroimaging Initiative to advancing AD research: a targeted review of recent publications.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Can Psychiatric Genetics Advance Without Incorporating a Life Course Perspective?Biological psychiatry · 2026Review
- Neuronal and glial networks interact with traumatic brain injury to modulate cognition in ABCD study.NPJ systems biology and applications · 2026Article
- Genetic modifiers of APOE-ε4-associated cognitive decline.Nature communications · 2026Article
- MST1 promotes microglial pyroptosis and neuroinflammation in alzheimer's disease by regulating the novel DPP8/NLRP1/Caspase-1/GSDMD-N axis.Journal of neuroinflammation · 2026Article
- APOE, ABCA7, and RASGEF1C are associated with earlier onset of amyloid deposition from more than 4000 harmonized positron emission tomography images.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- A multi-ancestry polygenic risk score for Alzheimer disease is associated with cognitive decline, hippocampal atrophy and neuropathological hallmarks in diverse populations.medRxiv : the preprint server for health sciences · 2025Article
- Novel modelling approaches to elucidate the genetic architecture of resilience to Alzheimer's disease.Brain : a journal of neurology · 2025Article
- Charting the shared genetic architecture of Alzheimer's disease, cognition, and educational attainment, and associations with brain development.Neurobiology of disease · 2024Article
- Essential New Complexity-Based Themes for Patient-Centered Diagnosis and Treatment of Dementia and Predementia in Older People: Multimorbidity and Multilevel Phenomenology.Journal of clinical medicine · 2024Review
- Overrepresentation of APOE ε4 carriers in genome-wide association studies of memory function and memory decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Sex differences and the role of estrogens in the immunological underpinnings of Alzheimer's disease.Alzheimer's & dementia (New York, N. Y.)Review
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Authors and funding
34 authors.
Derek B ArcherVanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jaclyn M EissmanVanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Shubhabrata MukherjeeDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Michael L LeeDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Seo-Eun ChoiDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Phoebe ScollardDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Emily H TrittschuhDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA.
Jesse B MezDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
William S BushCleveland Institute for Computational Biology, Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
Brian W KunkleJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.
Adam C NajDepartment of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Katherine A GiffordVanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Alzheimer's Disease Neuroimaging Initiative (ADNI)
Alzheimer's Disease Genetics Consortium (ADGC)
Alzheimer's Disease Sequencing Project (ADSP)
Michael L CuccaroJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.
Margaret A Pericak-VanceJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.
Lindsay A FarrerDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Li-San WangPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Gerard D SchellenbergPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Richard P MayeuxColumbia University, New York, New York, USA.
Jonathan L HainesCleveland Institute for Computational Biology, Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
Angela L JeffersonVanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Walter A KukullDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA.
C Dirk KeeneDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
Andrew J SaykinDepartment of Radiology and Imaging Services, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Paul M ThompsonImaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
Eden R MartinJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Lisa L BarnesRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Julie A SchneiderRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Paul K CraneDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Logan DumitrescuVanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Timothy J HohmanVanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-3377-7014
Funding
Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI Duygu Tosun-Turgut · 2016 to 2026
$226.7MAlzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0MNational Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MTranslational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI Christine L MacDonald · 2021 to 2026
$80.4MNATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8MSmartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5MAlzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4MThe natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1MNational Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MTBDU19AG068753 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Lindsay A. Farrer · 2020 to 2026
$42.4MNCATS NIH HHS UL1 TR000445NHGRI NIH HHS U01 HG004610NIA NIH HHS F31 AG077791NIA NIH HHS K01 AG049164NIA NIH HHS K01 AG073584NIA NIH HHS K23 AG045966NIA NIH HHS K24 AG046373NIA NIH HHS L30 AG060964NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P20 AG068024NIA NIH HHS P20 AG068053NIA NIH HHS P20 AG068077NIA NIH HHS P20 AG068082NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG062421NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG062677NIA NIH HHS P30 AG062715NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066462NIA NIH HHS P30 AG066468NIA NIH HHS P30 AG066506NIA NIH HHS P30 AG066507NIA NIH HHS P30 AG066508NIA NIH HHS P30 AG066509NIA NIH HHS P30 AG066511NIA NIH HHS P30 AG066512NIA NIH HHS P30 AG066514NIA NIH HHS P30 AG066515NIA NIH HHS P30 AG066518NIA NIH HHS P30 AG066519NIA NIH HHS P30 AG066530NIA NIH HHS P30 AG066546NIA NIH HHS P30 AG072931NIA NIH HHS P30 AG072946NIA NIH HHS P30 AG072947NIA NIH HHS P30 AG072958NIA NIH HHS P30 AG072959NIA NIH HHS P30 AG072972NIA NIH HHS P30 AG072973NIA NIH HHS P30 AG072975NIA NIH HHS P30 AG072976NIA NIH HHS P30 AG072977NIA NIH HHS P30 AG072978NIA NIH HHS P30 AG072979NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG019085NIA NIH HHS R01 AG022018NIA NIH HHS R01 AG030146NIA NIH HHS R01 AG034962NIA NIH HHS R01 AG036042NIA NIH HHS R01 AG036836NIA NIH HHS R01 AG042210NIA NIH HHS R01 AG044546NIA NIH HHS R01 AG048015NIA NIH HHS R01 AG048927NIA NIH HHS R01 AG056534NIA NIH HHS R01 AG059716NIA NIH HHS R01 AG061518NIA NIH HHS R01 AG062634NIA NIH HHS R01 AG062826NIA NIH HHS R01 AG064614NIA NIH HHS R01 AG064877NIA NIH HHS R01 AG073439NIA NIH HHS R01 AG079280NIA NIH HHS R21 AG059941NIA NIH HHS RC2 AG036528NIA NIH HHS RC2 AG036547NIA NIH HHS RC2 AG036650NIA NIH HHS RF1 AG053303NIA NIH HHS RF1 AG054080NIA NIH HHS RF1 AG057473NIA NIH HHS RF1 AG058501NIA NIH HHS U01 AG006781NIA NIH HHS U01 AG016976NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG032984NIA NIH HHS U01 AG046152NIA NIH HHS U01 AG046161NIA NIH HHS U01 AG052410NIA NIH HHS U01 AG058654NIA NIH HHS U01 AG058922NIA NIH HHS U01 AG061356NIA NIH HHS U01 AG068057NIA NIH HHS U19 AG024904NIA NIH HHS U19 AG066567NIA NIH HHS U19 AG068753NIA NIH HHS U24 AG021886NIA NIH HHS U24 AG041689NIA NIH HHS U24 AG056270NIA NIH HHS U24 AG072122NIA NIH HHS U24 AG074855NIA NIH HHS U54 AG052427NICHD NIH HHS K12 HD043483NIH HHS F31 AG077791NIH HHS HHSN311201600276PNIH HHS K01 AG049164NIH HHS K01 AG073584NIH HHS K12 HD043483NIH HHS K23 AG045966NIH HHS K24 AG046373NIH HHS P01 AG003991NIH HHS P01 AG026276NIH HHS P20 AG068024NIH HHS P20 AG068053NIH HHS P20 AG068077NIH HHS P20 AG068082NIH HHS P30 AG010161NIH HHS P30 AG062421NIH HHS P30 AG062422NIH HHS P30 AG062429NIH HHS P30 AG062677NIH HHS P30 AG062715NIH HHS P30 AG066444NIH HHS P30 AG066462NIH HHS P30 AG066468NIH HHS P30 AG066506NIH HHS P30 AG066507NIH HHS P30 AG066508NIH HHS P30 AG066509NIH HHS P30 AG066511NIH HHS P30 AG066512NIH HHS P30 AG066514NIH HHS P30 AG066515NIH HHS P30 AG066518NIH HHS P30 AG066519NIH HHS P30 AG066530NIH HHS P30 AG066546NIH HHS P30 AG072931NIH HHS P30 AG072946NIH HHS P30 AG072947NIH HHS P30 AG072958NIH HHS P30 AG072959NIH HHS P30 AG072972NIH HHS P30 AG072973NIH HHS P30 AG072975NIH HHS P30 AG072976NIH HHS P30 AG072977NIH HHS P30 AG072978NIH HHS P30 AG072979NIH HHS P30 AG079280NIH HHS R01 AG015819NIH HHS R01 AG017917NIH HHS R01 AG022018NIH HHS R01 AG030146NIH HHS R01 AG034962NIH HHS R01 AG036042NIH HHS R01 AG036836NIH HHS R01 AG044546NIH HHS R01 AG048015NIH HHS R01 AG048927NIH HHS R01 AG056534NIH HHS R01 AG059716NIH HHS R01 AG061518NIH HHS R01 AG062634NIH HHS R01 AG064614NIH HHS R01 AG064877NIH HHS R01 AG073439NIH HHS R01 AG42210NIH HHS R01 NS100980NIH HHS R21 AG059941NIH HHS RC2 AG036528NIH HHS RC2 AG036547NIH HHS RF1 AG053303NIH HHS RF1 AG054080NIH HHS RF1 AG057473NIH HHS RF1 AG058501NIH HHS S10 OD023680NIH HHS U01 AG006781NIH HHS U01 AG016976NIH HHS U01 AG024904NIH HHS U01 AG032984NIH HHS U01 AG046152NIH HHS U01 AG046161NIH HHS U01 AG052410NIH HHS U01 AG058654NIH HHS U01 AG058922NIH HHS U01 AG061356NIH HHS U01 AG068057NIH HHS U19 AG066567NIH HHS U19 AG068753NIH HHS U24 AG021886NIH HHS U24 AG041689NIH HHS U24 AG056270NIH HHS U24 AG072122NIH HHS U24 AG074855NIH HHS U54 AG052427NIH HHS UL1 TR000445NINDS NIH HHS R01 NS100980NINDS NIH HHS UF1 NS100598
Abstract
introductionAlthough large-scale genome-wide association studies (GWAS) have been conducted on AD, few have been conducted on continuous measures of memory performance and memory decline.
methodsWe conducted a cross-ancestry GWAS on memory performance (in 27,633 participants) and memory decline (in 22,365 participants; 129,201 observations) by leveraging harmonized cognitive data from four aging cohorts.
resultsWe found high heritability for two ancestry backgrounds. Further, we found a novel ancestry locus for memory decline on chromosome 4 (rs6848524) and three loci in the non-Hispanic Black ancestry group for memory performance on chromosomes 2 (rs111471504), 7 (rs4142249), and 15 (rs74381744). In our gene-level analysis, we found novel genes for memory decline on chromosomes 1 (SLC25A44), 11 (BSX), and 15 (DPP8). Memory performance and memory decline shared genetic architecture with AD-related traits, neuropsychiatric traits, and autoimmune traits. DISCUSSION: We discovered several novel loci, genes, and genetic correlations associated with late-life memory performance and decline. HIGHLIGHTS: Late-life memory has high heritability that is similar across ancestries. We discovered four novel variants associated with late-life memory. We identified four novel genes associated with late-life memory. Late-life memory shares genetic architecture with psychiatric/autoimmune traits.
Indexed as
Alzheimer DiseaseCognitionEndophenotypesGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMemory DisordersPolymorphism, Single NucleotideAlzheimer's diseasegeneticsGWASmemory
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