Evidence map›Paper›PMID 37984884›Full record

ArticleAngewandte Chemie (International ed. in English)2024

α-Functionalisation of Cyclic Sulfides Enabled by Lithiation Trapping.

Nico Seling, Masakazu Atobe, Kevin Kasten, James D Firth, Peter B Karadakov, Frederick W Goldberg, Peter O'Brien

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. α-Functionalisation of Cyclic Sulfides Enabled by Lithiation Trapping.Angewandte Chemie (International ed. in English) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nico SelingDepartment of Chemistry, University of York, York, YO10 5DD, UK.ORCID https://orcid.org/0000-0002-8731-2677
Masakazu AtobeDepartment of Chemistry, University of York, York, YO10 5DD, UK.ORCID https://orcid.org/0000-0002-7314-0237
Kevin KastenDepartment of Chemistry, University of York, York, YO10 5DD, UK.ORCID https://orcid.org/0000-0003-1298-8784
James D FirthDepartment of Chemistry, University of York, York, YO10 5DD, UK.ORCID https://orcid.org/0000-0003-2283-552X
Peter B KaradakovDepartment of Chemistry, University of York, York, YO10 5DD, UK.ORCID https://orcid.org/0000-0002-2673-6804
Frederick W GoldbergOncology R&D, AstraZeneca, 1 Francis Crick Ave, Cambridge, CB2 0AA, UK.ORCID https://orcid.org/0000-0002-4874-1700
Peter O'BrienDepartment of Chemistry, University of York, York, YO10 5DD, UK.ORCID https://orcid.org/0000-0002-9966-1962

Funding

Asahi Kasei Pharma CorporationEngineering and Physical Sciences Research Council EP/P011217/1Engineering and Physical Sciences Research Council EP/V048139/1Royal Society INF\R1\191028
6 · The paper itself

Abstract

A general and straightforward procedure for the lithiation trapping of cyclic sulfides such as tetrahydrothiophene, tetrahydrothiopyran and a thiomorpholine is described. Trapping with a wide range of electrophiles is demonstrated, leading to more than 50 diverse α-substituted saturated sulfur heterocycles. The methodology provides access to a range of α-substituted cyclic sulfides that are not easily synthesised by the currently available methods.

Indexed as

Cyclic SulfidesOrganolithiumα-Functionalization

Identifiers

PMID37984884
PMCPMC10952194

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.