ArticleOrthopaedic surgery2024
Admission Inflammation Markers Influence Long-term Mortality in Elderly Patients Undergoing Hip Fracture Surgery: A Retrospective Cohort Study.
Article in Orthopaedic surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Association of multidimensional biomarkers of immune, nutritional, inflammatory, and metabolic status with postoperative outcomes in older hip fracture patients: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Neutrophil-to-lymphocyte ratio for predicting postoperative mortality after hip fracture surgery: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- Anti-inflammatory effect of multi-dose tranexamic acid in hip and knee arthroplasty: a systematic review and meta-analysis of randomized controlled trials.Inflammopharmacology · 2025Pooled it
- Impact of hematologic inflammatory markers on the prognosis of geriatric hip fracture: a systematic review and meta-analysis.European journal of medical research · 2024Pooled it
- Explainable Multimodal Machine Learning Predicts 90-Day Treatment Failure in Older Patients with Fragility Fractures of the Pelvis.Journal of clinical medicine · 2026Article
- Article
- Predictive Value of the CRP/Albumin Ratio in Mortality Prediction in Hip Fracture Surgery Patients Admitted to Intensive Care.Life (Basel, Switzerland) · 2026Article
- A retrospective study on the application of unilateral epidural anesthesia in older patients with hip fracture.BMC geriatrics · 2026Article
- Enzyme-regulated biomineralization: Biological functions and advanced biomaterials for tissue regeneration.Bioactive materials · 2026Review
- The preoperative BUN-to-albumin ratio predicts early mortality after geriatric intertrochanteric fracture surgery: a retrospective cohort study.Journal of orthopaedic surgery and research · 2026Article
- Risk Factors Associated with Complications and Early Mortality of Hip Fracture Surgery in Elderly Patients.Medicina (Kaunas, Lithuania) · 2026Article
- Temporal Changes in Key Hematological and Inflammatory-Immune Markers Among Elderly Patients Following Hip Fracture: A Five-Day Serial Assessment.Orthopaedic surgery · 2026Article
- Establishment and validation of a clinical prediction model for perioperative pneumonia in elderly patients with hip fractures combined with preoperative stroke.Frontiers in medicine · 2026Article
- C-reactive protein -albumin-lymphocyte (CALLY) index as a predictor of early mortality in elderly patients with hip fractures.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2025Article
- Relationship between mortality and HALP score in femoral neck fractures treated with hemiarthroplasty.Joint diseases and related surgery · 2025Article
- The Akcaalan Mortality Score: A Novel Mortality Score to Predict 3-Year Mortality for Elderly Hip Fractures.Journal of clinical medicine · 2025Article
- Article
- Immunomodulatory factors CRP/albumin ratio and NLR predict post-spinal surgery infection.Frontiers in surgery · 2025Article
- A novel indicator for predicting functional recovery in elderly hip fracture patients.Frontiers in medicine · 2025Article
- Associations between sarcopenia (defined by low muscle mass), inflammatory markers, and all-cause mortality in older adults: mediation analyses in a large U.S. NHANES community sample, 1999-2006.Frontiers in medicine · 2025Article
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7 authors.
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Abstract
objectivesHip fractures in elderly patients are associated with a high mortality rate. Most deaths associated with hip fracture result from complications after surgery. Recent studies suggest that some inflammation biomarkers may be useful to estimate excess mortality. This study aimed to investigate the prognostic value of admission inflammation biomarkers in elderly patients with hip fracture.
methodsWe reports on a retrospective study of elderly hip fracture patients admitted to a hospital in China between January 2015 and December 2019. A total of 1085 patients were included in the study, and their demographic and pre-operative characteristics were analyzed. The inflammation biomarkers included monocyte to lymphocyte ratio (MLR), neutrophil to lymphocyte ratio (NLR), and C-reactive protein (CRP) to albumin ratio (CAR). The predictive performance of NLR, MLR and CAR was assessed by receiver operating characteristics (ROC) curve analysis and the association between admission inflammation markers and mortality was evaluated by Cox proportional regression.
resultsThe 30-day, 1-year, 2-year, and 4-year mortality were 1.6%, 11.5%, 21.4% and 48.9%, respectively. The optimal cut-off values of admission NLR, MLR and CAR for 1-year mortality were 7.28, 0.76, and 1.36. After adjusting the covariates, preoperative NLR ≥ 7.28 (HR = 1.419, 95% CI: 1.080-1.864, p = 0.012) were found to be only independent risk factors with 4-year all-cause mortality, the preoperative CAR ≥ 1.36 was independently associated with 1-year (HR = 1.700, 95% CI: 1.173-2.465, p = 0.005), 2 year (HR = 1.464, 95% CI: 1.107-1.936, p = 0.008), and 4-year (HR = 1.341, 95% CI: 1.057-1.700, p = 0.016) all-cause mortality, While age, CCI score, and low hemoglobin at admission were also risk factors for postoperative all-cause mortality.
conclusionAdmission CAR and NLR may be useful indicators for predicting the long-term mortality of elderly patients undergoing hip fracture surgery, and that more research is needed to validate these findings.
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