Evidence map›Paper›PMID 37984228›Full record

ArticleSeminars in arthritis and rheumatism2024

Obesity is an independent risk factor for cancer development following diagnosis of dermatomyositis.

Astia Allenzara, Nakisa Sadeghi, Carolina Alvarez, Steve Maczuga, Matthew Helm, Nancy Olsen, Amanda Nelson, Galen Foulke

Abstract read
In one paragraph

Article in Seminars in arthritis and rheumatism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Epidemiology of myositis.Current opinion in rheumatology · 2025
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Astia AllenzaraUniversity of North Carolina at Chapel Hill, Division of Rheumatology, Allergy and Immunology and Thurston Arthritis Research Center, Chapel Hill, NC, USA. Electronic address: astia.allenzara@unchealth.unc.edu.
Nakisa SadeghiUniversity of North Carolina, School of Medicine, Chapel Hill, NC, USA.
Carolina AlvarezUniversity of North Carolina at Chapel Hill, Division of Rheumatology, Allergy and Immunology and Thurston Arthritis Research Center, Chapel Hill, NC, USA.
Steve MaczugaPenn State Health Milton S Hershey Medical Center, Department of Dermatology, Hershey, PA, USA.
Matthew HelmPenn State Health Milton S Hershey Medical Center, Department of Dermatology, Hershey, PA, USA.
Nancy OlsenPenn State Health Milton S Hershey Medical Center, Division of Rheumatology, Hershey, PA, USA.
Amanda NelsonUniversity of North Carolina at Chapel Hill, Division of Rheumatology, Allergy and Immunology and Thurston Arthritis Research Center, Chapel Hill, NC, USA; University of North Carolina, School of Medicine, Chapel Hill, NC, USA.
Galen FoulkePenn State Health Milton S Hershey Medical Center, Department of Dermatology, Hershey, PA, USA; Penn State Health Milton S Hershey Medical Center, Department of Public Health Sciences, Hershey, PA, USA.

Funding

UNC Core Center for Clinical ResearchP30AR072580 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Amanda E Nelson · 2019 to 2026
$6.1M
Mentoring in Patient Oriented Research in OsteoarthritisK24AR081368 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Amanda E Nelson · 2022 to 2026
$916k
NIAMS NIH HHS K24 AR081368NIAMS NIH HHS P30 AR072580
6 · The paper itself

Abstract

Patients with dermatomyositis (DM) are at an increased risk of cancer development, especially around the time of diagnosis of DM. Obesity is also a risk factor in the general population for cancer development. This study aimed to assess the association between cancer in DM patients with and without obesity as defined by ICD code and BMI data. In this analysis of patients with DM, logistic regression modeling of the odds of cancer outcome was performed for patients with DM and obesity compared to those without obesity, adjusted for age and sex. A total of 12,722 patients with DM were identified, of whom 6,055 had available BMI data. DM patients who were coded obese at any point had significantly higher odds 1.98 (95 % Confidence interval (CI) 1.70, 2.30) of a subsequent cancer diagnosis. This association was also found in the subgroup analysis with available BMI where patients with obesity (BMI ≥30 kg/m

Indexed as

DermatomyositisNeoplasmsHumansObesityRetrospective StudiesRisk FactorsDermatomyositisEarly detection of cancerMalignancyObesity

Identifiers

PMID37984228
PMCPMC10842776

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.