Evidence map›Paper›PMID 37984017›Full record

ArticleSleep medicine2024

Pontine parabrachial nucleus-basal forebrain circuitry regulating cortical and hippocampal arousal.

Yudan Lv, Yujun Wen, Ramalingam Vetrivelan, Jun Lu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. The Somatostatin Pathway Projected from the Basal Forebrain to the Lateral Habenula Promotes Isoflurane Anesthesia Recovery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Yudan LvDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, Jilin, China; Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. Electronic address: lvyudan@sina.com.
Yujun WenDepartment of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA; Ningxia Key Laboratory of Craniocerebral Diseases, Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, China. Electronic address: wenyj@nxmu.edu.cn.
Ramalingam VetrivelanDepartment of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. Electronic address: vramalin@bidmc.harvard.edu.
Jun LuDepartment of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA; Stroke Center, The First Hospital of Jilin University, Changchun, Jilin, China. Electronic address: lujun@jlu.edu.cn.
Beth Israel Deaconess Medical Center · USFirst Hospital of Jilin University · CNHarvard University · US

Funding

Neural Mechanisms Underlying Cataplexy Control by MCH NeuronsR01NS119223 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RAMALINGAM, VETRIVELAN · 2021 to 2025
$2.2M
Parabrachial nucleus control of arousalR01NS095986 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LU, JUN · 2016 to 2020
$1.9M
NINDS NIH HHS R01 NS095986NINDS NIH HHS R01 NS119223
6 · The paper itself

Abstract

introductionThe basal forebrain (BF) and the medial septum (MS) respectively drive neuronal activity of cerebral cortex and hippocampus (HPC) in sleep-wake cycle. Our previous studies of lesions and neuronal circuit tracing have shown that the pontine parabrachial nucleus (PB) projections to the BF and MS may be a key circuit for cortical and HPC arousal.

aimsThis study aims to demonstrate that PB projections to the BF and MS activate the cerebral cortex and HPC.

resultsBy using chemogenetic stimulation of the BF, the PB-BF and the PB-MS pathway combined with electroencephalogram (EEG) Fast Fourier Transformation (FFT) analysis in rats, we demonstrated that chemogenetic stimulation of the BF or PB neurons projecting to the BF activated the cerebral cortex while chemogenetic stimulation of the MS or PB neurons projecting to the MS activated HPC activity, in sleep and wake state. These stimulations did not significantly alter sleep-wake amounts.

conclusionsOur results support that PB projections to the BF and MS specifically regulating cortical and HPC activity.

Indexed as

Basal ForebrainParabrachial NucleusAnimalsArousalElectroencephalographyHippocampusRatsWakefulnessAscending reticular activating systemBasal forebrainCortical arousalElectroencephalogramMedial septumParabrachial nucleus

Identifiers

PMID37984017
PMCPMC12039854
OpenAlexW4388570884

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.