Evidence map›Paper›PMID 37983568›Full record

ArticleGenes, brain, and behavior2023

PAC1 receptor modulation of freezing and flight behavior in periaqueductal gray.

Ersin Yavas, Irina Zhuravka, Michael S Fanselow

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, brain, and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Ersin YavasDepartment of Psychology, Bartın University, Bartın, Turkey.ORCID 0000-0002-5128-3106
Irina ZhuravkaStaglin Center for Brain and Behavioral Health, Department of Psychology, UCLA, Los Angeles, California, USA.
Michael S FanselowStaglin Center for Brain and Behavioral Health, Department of Psychology, UCLA, Los Angeles, California, USA.
UCLA Health · USBartin University · TR

Funding

Acute vs Chronic Stress-Enhanced Fear LearningR01MH115678 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FANSELOW, MICHAEL S · 2018 to 2022
$1.9M
PACAP Signaling in Fear Circuitries Relevant to Post-Traumatic Stress DisorderR21MH098506 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FANSELOW, MICHAEL S, WASCHEK, JAMES A · 2013 to 2014
$424k
NIH HHS R01-MH115678NIMH NIH HHS R01 MH115678NIMH NIH HHS R21 MH098506
6 · The paper itself

Abstract

The midbrain periaqueductal gray (PAG) region is a critical anatomical regulator of fear-related species-specific defensive reactions (SSDRs). Pituitary adenylate-cyclase-activating polypeptide (PACAP), and its main receptor PAC1, play an important role in fear-related behavior and anxiety disorders. However, the function of the PACAP-PAC1 system within the PAG with regards to SSDRs has received little attention. To address this gap, we used transgenic PAC1

Indexed as

Pituitary Adenylate Cyclase-Activating PolypeptideReceptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type IAnimalsFearMicePeriaqueductal GrayAdcyap1r1 protein, mousePituitary Adenylate Cyclase-Activating PolypeptideReceptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type Idartingearly gene expressionfear conditioningfreezingPAC1 receptorperiaqueductal grayVGAT

Identifiers

PMID37983568
PMCPMC10733566
OpenAlexW4388852330

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.