Evidence map›Paper›PMID 37983567›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Lactobacillus Intestinalis Primes Epithelial Cells to Suppress Colitis-Related Th17 Response by Host-Microbe Retinoic Acid Biosynthesis.

Qi-Wen Wang, Ding-Jia-Cheng Jia, Jia-Min He, Yong Sun, Yun Qian, Qi-Wei Ge, Ya-Dong Qi, Qing-Yi Wang, Ying-Ying Hu, Lan Wang and 8 more

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
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  8. Asiatic acid fromFrontiers in nutrition · 2026
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  10. Combined polysaccharides fromFrontiers in microbiology · 2026
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  12. Machine learning reveals targets ofFrontiers in immunology · 2026
    Article
  13. The Probiotic Effects ofInternational journal of microbiology · 2026
    Article
  14. Article
  15. Gut microbes · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Food science & nutrition · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Qi-Wen WangDepartment of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Ding-Jia-Cheng JiaDepartment of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China.
Jia-Min HeDepartment of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Yong SunDepartment of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China.
Yun QianDepartment of Gastroenterology and Hepatology, Shenzhen University General Hospital, Shenzhen, Guangdong, 518055, China.
Qi-Wei GeDepartment of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China.
Ya-Dong QiDepartment of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Qing-Yi WangDepartment of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Ying-Ying HuDepartment of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Lan WangDepartment of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Yan-Fei FangDepartment of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Hui-Qin HeDepartment of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Man LuoDepartment of Nutrition, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Li-Jun FengDepartment of Nutrition, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Jian-Min SiDepartment of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Zhang-Fa SongDepartment of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Liang-Jing WangDepartment of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China.
Shu-Jie ChenDepartment of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, 310058, China.ORCID 0000-0001-9523-0033
Sir Run Run Shaw Hospital · CNSecond Affiliated Hospital of Zhejiang University · CNShenzhen University · CN

Funding

Medicine and Health Research Project of Zhejiang 2021KY732National Natural Science Foundation of China 82270573National Natural Science Foundation of China 82370556Natural Science Foundation of Shenzhen City JCYJ20190808115003699Natural Science Foundation of Zhejiang Province LQ19H030006
6 · The paper itself

Abstract

Gut microbiome is integral to the pathogenesis of ulcerative colitis. A novel probiotic Lactobacillus intestinalis (L. intestinalis) exerts a protective effect against dextran sodium sulfate-induced colitis in mice. Based on flow cytometry, colitis-associated Th17 cells are the target of L. intestinalis, which is supported by the lack of protective effects of L. intestinalis in T cell-null Rag1

Indexed as

ColitisColitis, UlcerativeAnimalsEpithelial CellsHumansLactobacillusMiceTh17 CellsTretinoinTretinoincolitismicrobesretinoic acidTh17

Identifiers

PMID37983567
PMCPMC10754072
OpenAlexW4388869324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.