Evidence map›Paper›PMID 37983525›Full record

ArticleDiabetes2023

An Intraislet Paracrine Signaling Pathway That Enables Glucagon to Stimulate Pancreatic β-Cells.

Alejandro Caicedo, Mark O Huising, Jürgen Wess

Open access · bronzeAbstract readEditorialComment
In one paragraph

Article in Diabetes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. REVISITING GLUCAGON ACTION IN DIABETES: IS IT ALL BAD?Transactions of the American Clinical and Climatological Association · 2025
    Review
  5. Review
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Alejandro CaicedoDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL.ORCID 0000-0002-3765-3529
Mark O HuisingDepartment of Neurobiology, Physiology and Behavior, College of Biological Sciences, University of California, Davis, Davis, CA.ORCID 0000-0002-6594-2205
Jürgen WessMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD.ORCID 0000-0003-0818-1232
National Institute of Diabetes and Digestive and Kidney Diseases · USUniversity of California, Davis · USUniversity of Miami · US

Funding

PARACRINE FEEDBACK BY PANCREATIC DELTA CELLS TO CONTROL GLUCAGON AND INSULIN RELEASE AND MANAGE DIABETESR01DK110276 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Mark O. Huising · 2017 to 2026
$3.9M
In situ analysis of functional endocrine, vascular, and immune cell interactions during early postnatal development of the human pancreasU01DK120456 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BRISSOVA, MARCELA, CAICEDO, ALEJANDRO · 2018 to 2021
$2.6M
FFA4 regulation of pancreatic islet functionR01DK132597 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HUISING, MARK O., POITOUT, VINCENT · 2022 to 2025
$1.9M
The Role of Innervation for Hormone Secretion in Human IsletsR01DK084321 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CAICEDO, ALEJANDRO · 2011 to 2015
$1.8M
Harnessing Innervation to Promote Pancreatic Islet FunctionR01DK113093 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CAICEDO, ALEJANDRO · 2017 to 2020
$1.5M
Cholinergic signaling in the human pancreatic isletR01DK111538 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CAICEDO, ALEJANDRO · 2016 to 2018
$1.2M
NIDDK NIH HHS R01 DK084321NIDDK NIH HHS R01 DK110276NIDDK NIH HHS R01 DK111538NIDDK NIH HHS R01 DK113093NIDDK NIH HHS R01 DK132597NIDDK NIH HHS U01 DK120456
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Glucagon-Secreting CellsInsulin-Secreting CellsIslets of LangerhansGlucagonInsulinParacrine CommunicationGlucagonInsulin

Identifiers

PMID37983525
PMCPMC10658067
OpenAlexW4388819269

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.