ArticleProceedings of the National Academy of Sciences of the United States of America2023
Optimal information loading into working memory explains dynamic coding in the prefrontal cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Reusable modular architecture enables flexible cognitive operations in the mouse brain and artificial recurrent networks.Nature neuroscience · 2026Article
- Neural dynamics underlying minute-timescale persistent behaviour in the human brain.Nature human behaviour · 2026Article
- Data-driven reduced modeling of neural dynamics.Nature communications · 2026Article
- Reversed functional gradient in primate prefrontal cortex: Posterior dominance and frontopolar task-related deactivation.Science advances · 2026Article
- Article
- Conjunctive population coding integrates sensory evidence to guide adaptive behavior.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Neural dynamics outside task-coding dimensions drive decision trajectories through transient amplification.bioRxiv : the preprint server for biology · 2025Article
- Complex functions of human lateral frontopolar cortex.Brain : a journal of neurology · 2025Review
- Hierarchical dynamic coding coordinates speech comprehension in the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Reusable modular architecture enables flexible cognitive operations.Research square · 2025Article
- Embodied sensorimotor control: computational modeling of the neural control of movement.ArXiv · 2025Article
- Hierarchical dynamic coding coordinates speech comprehension in the human brain.bioRxiv : the preprint server for biology · 2025Article
- Ramping dynamics in the frontal cortex unfold over multiple timescales during motor planning.Journal of neurophysiology · 2025Article
- Article
- Inferring context-dependent computations through linear approximations of prefrontal cortex dynamics.Science advances · 2024Article
- Timescales of learning in prefrontal cortex.Nature reviews. Neuroscience · 2024Review
- Working memory expedites the processing of visual signals within the extrastriate cortex.iScience · 2024Article
- Ramping Dynamics in the Frontal Cortex Unfold Over Multiple Timescales During Motor Planning.bioRxiv : the preprint server for biology · 2024Article
- Recurrent neural network dynamical systems for biological vision.Advances in neural information processing systems · 2024Article
- Training biologically plausible recurrent neural networks on cognitive tasks with long-term dependencies.bioRxiv : the preprint server for biology · 2023Article
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5 authors.
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Abstract
Working memory involves the short-term maintenance of information and is critical in many tasks. The neural circuit dynamics underlying working memory remain poorly understood, with different aspects of prefrontal cortical (PFC) responses explained by different putative mechanisms. By mathematical analysis, numerical simulations, and using recordings from monkey PFC, we investigate a critical but hitherto ignored aspect of working memory dynamics: information loading. We find that, contrary to common assumptions, optimal loading of information into working memory involves inputs that are largely orthogonal, rather than similar, to the late delay activities observed during memory maintenance, naturally leading to the widely observed phenomenon of dynamic coding in PFC. Using a theoretically principled metric, we show that PFC exhibits the hallmarks of optimal information loading. We also find that optimal information loading emerges as a general dynamical strategy in task-optimized recurrent neural networks. Our theory unifies previous, seemingly conflicting theories of memory maintenance based on attractor or purely sequential dynamics and reveals a normative principle underlying dynamic coding.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.