Evidence map›Paper›PMID 37983312›Full record

ArticleJournal of proteome research2023

Metabolomic, Proteomic, and Single-Cell Proteomic Analysis of Cancer Cells Treated with the KRAS

Benjamin C Orsburn

Open access · greenAbstract read
In one paragraph

Article in Journal of proteome research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  12. Analyzing Posttranslational Modifications in Single Cells.Methods in molecular biology (Clifton, N.J.) · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Benjamin C OrsburnThe Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.ORCID 0000-0002-0774-3750
Johns Hopkins University · US

Funding

Cellular Signaling in Drug Induced ToxicityR01GM103853 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ORSBURN, BENJAMIN CARL · 2013 to 2022
$3.6M
Drug Phosphorylation and AgingR01AG064908 · NIA · JOHNS HOPKINS UNIVERSITY · PI ORSBURN, BENJAMIN CARL · 2020 to 2023
$2.4M
Thermo-Scientific Q Exactive Plus Orbitrap LC-MS/MS SystemS10OD025226 · OD · JOHNS HOPKINS UNIVERSITY · PI LE, ANNE · 2018 to 2018
$562k
NIA NIH HHS R01 AG064908NIGMS NIH HHS R01 GM103853NIH HHS S10 OD025226
6 · The paper itself

Abstract

Mutations in KRAS are common drivers of human cancers and are often those with the poorest overall prognosis for patients. A recently developed compound, MRTX1133, has shown promise in inhibiting the activity of KRAS

Indexed as

Pancreatic NeoplasmsProto-Oncogene Proteins p21(ras)Heterocyclic Compounds, 2-RingHumansMutationNaphthalenesProteomicsHeterocyclic Compounds, 2-RingKRASG12D inhibitor MRTX1133KRAS protein, humanNaphthalenesProto-Oncogene Proteins p21(ras)KRASmetabolomicsMRTX1133proteomicssingle-cell proteomics

Identifiers

PMID37983312
PMCPMC10696623
OpenAlexW4388820104

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.